UBE2J2 [The Human Chemical-Genetic Interaction Map Project]

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======= UBE2J2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UBE2J2
  * **<color #00a2e8>Official Name</color>**: ubiquitin conjugating enzyme E2 J2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=118424|118424]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N2K1|Q8N2K1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UBE2J2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UBE2J2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619756|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD). {ECO:0000255|PROSITE-ProRule:PRU00388}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|UQ con|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of protein targeting to mitochondrion|
|ubiquitin conjugating enzyme activity|
|regulation of protein targeting to mitochondrion|
|positive regulation of establishment of protein localization to mitochondrion|
|ubiquitin-dependent ERAD pathway|
|regulation of establishment of protein localization to mitochondrion|
|regulation of protein targeting|
|ERAD pathway|
|ubiquitin ligase complex|
|positive regulation of mitochondrion organization|
|positive regulation of intracellular protein transport|
|response to unfolded protein|
|regulation of mitochondrion organization|
|response to topologically incorrect protein|
|positive regulation of intracellular transport|
|regulation of intracellular protein transport|
|response to endoplasmic reticulum stress|
|ubiquitin protein ligase binding|
|protein polyubiquitination|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|positive regulation of cellular protein localization|
|proteasomal protein catabolic process|
|regulation of intracellular transport|
|positive regulation of protein transport|
|positive regulation of establishment of protein localization|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|regulation of cellular protein localization|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|positive regulation of organelle organization|
|protein catabolic process|
|protein ubiquitination|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|protein modification by small protein conjugation|
|cellular macromolecule catabolic process|
|regulation of cellular localization|
|endoplasmic reticulum membrane|
|protein modification by small protein conjugation or removal|
|positive regulation of transport|
|response to organonitrogen compound|
|endoplasmic reticulum|
|regulation of protein localization|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|response to nitrogen compound|
|positive regulation of cellular component organization|
|proteolysis|
|regulation of organelle organization|
|ATP binding|
|cellular response to stress|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|-1.91|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|-1.75|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|-1.72|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|1.82|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|1.96|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 8/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|1/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|1/20|
|lung|1/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5307
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.42 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UBE2J2 Expression in NALM6 Cells: 5.42'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>