UBE2QL1 [The Human Chemical-Genetic Interaction Map Project]

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======= UBE2QL1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UBE2QL1
  * **<color #00a2e8>Official Name</color>**: ubiquitin conjugating enzyme E2 Q family like 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=134111|134111]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/A1L167|A1L167]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UBE2QL1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UBE2QL1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615832|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Probable E2 ubiquitin-protein ligase that catalyzes the covalent attachment of ubiquitin to target proteins. May facilitate the monoubiquitination and degradation of MTOR and CCNE1 through interaction with FBXW7. {ECO:0000269|PubMed:24000165}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|UQ con|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ubiquitin conjugating enzyme activity|
|protein ubiquitination|
|protein modification by small protein conjugation|
|protein modification by small protein conjugation or removal|
|ATP binding|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|-2.52|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|-2.3|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|-2.19|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|-2.06|
|[[:results:exp293|Myriocin 25μM R06 exp293]]|-1.9|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|-1.81|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-1.8|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|-1.8|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|-1.76|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-1.75|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-1.74|
|[[:results:exp101|Nicotinamide 1000μM R03 exp101]]|-1.74|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|-1.73|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|-1.7|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|2.12|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13784
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UBE2QL1 Expression in NALM6 Cells: -4.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>