UBQLN1 [The Human Chemical-Genetic Interaction Map Project]

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======= UBQLN1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UBQLN1
  * **<color #00a2e8>Official Name</color>**: ubiquilin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=29979|29979]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UMX0|Q9UMX0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UBQLN1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UBQLN1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605046|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an ubiquitin-like protein (ubiquilin) that shares a high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to modulate accumulation of presenilin proteins, and it is found in lesions associated with Alzheimer's and Parkinson's disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Rad60-SLD|
|UBA|
|ubiquitin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of store-operated calcium channel activity|
|negative regulation of toll-like receptor 3 signaling pathway|
|positive regulation of ER-associated ubiquitin-dependent protein catabolic process|
|aggrephagy|
|regulation of store-operated calcium channel activity|
|regulation of ER-associated ubiquitin-dependent protein catabolic process|
|regulation of toll-like receptor 3 signaling pathway|
|positive regulation of ERAD pathway|
|selective autophagy|
|regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|
|regulation of ERAD pathway|
|polyubiquitin modification-dependent protein binding|
|autophagosome maturation|
|negative regulation of calcium ion transmembrane transporter activity|
|positive regulation of response to endoplasmic reticulum stress|
|negative regulation of toll-like receptor signaling pathway|
|negative regulation of calcium ion transmembrane transport|
|negative regulation of cation channel activity|
|aggresome|
|proteasome complex|
|negative regulation of calcium ion transport|
|autophagosome assembly|
|regulation of oxidative stress-induced cell death|
|autophagosome organization|
|regulation of toll-like receptor signaling pathway|
|autophagosome|
|negative regulation of ion transmembrane transporter activity|
|ubiquitin-dependent ERAD pathway|
|regulation of cellular response to oxidative stress|
|negative regulation of transporter activity|
|negative regulation of cation transmembrane transport|
|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|
|regulation of response to endoplasmic reticulum stress|
|regulation of response to oxidative stress|
|regulation of calcium ion transmembrane transporter activity|
|ERAD pathway|
|kinase binding|
|negative regulation of ion transmembrane transport|
|positive regulation of ubiquitin-dependent protein catabolic process|
|positive regulation of proteasomal protein catabolic process|
|positive regulation of protein ubiquitination|
|negative regulation of transmembrane transport|
|positive regulation of proteolysis involved in cellular protein catabolic process|
|regulation of proteasomal ubiquitin-dependent protein catabolic process|
|vacuole organization|
|positive regulation of protein modification by small protein conjugation or removal|
|positive regulation of cellular protein catabolic process|
|negative regulation of ion transport|
|regulation of calcium ion transmembrane transport|
|regulation of ubiquitin-dependent protein catabolic process|
|regulation of intrinsic apoptotic signaling pathway|
|macroautophagy|
|regulation of cation channel activity|
|regulation of macroautophagy|
|regulation of proteasomal protein catabolic process|
|cellular response to hypoxia|
|cellular response to decreased oxygen levels|
|regulation of protein ubiquitination|
|cellular response to oxygen levels|
|regulation of proteolysis involved in cellular protein catabolic process|
|positive regulation of protein catabolic process|
|regulation of protein modification by small protein conjugation or removal|
|protein-containing complex disassembly|
|regulation of calcium ion transport|
|regulation of cellular protein catabolic process|
|cytoplasmic vesicle|
|response to endoplasmic reticulum stress|
|regulation of ion transmembrane transporter activity|
|process utilizing autophagic mechanism|
|autophagy|
|regulation of transmembrane transporter activity|
|regulation of transporter activity|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|regulation of autophagy|
|regulation of cation transmembrane transport|
|response to hypoxia|
|proteasomal protein catabolic process|
|response to decreased oxygen levels|
|positive regulation of proteolysis|
|positive regulation of cellular catabolic process|
|response to oxygen levels|
|regulation of protein catabolic process|
|regulation of metal ion transport|
|regulation of apoptotic signaling pathway|
|cellular component disassembly|
|positive regulation of catabolic process|
|negative regulation of immune system process|
|regulation of innate immune response|
|regulation of ion transmembrane transport|
|negative regulation of transport|
|regulation of response to biotic stimulus|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|regulation of transmembrane transport|
|proteolysis involved in cellular protein catabolic process|
|protein-containing complex|
|cellular protein catabolic process|
|protein catabolic process|
|perinuclear region of cytoplasm|
|regulation of ion transport|
|regulation of proteolysis|
|regulation of cellular response to stress|
|organelle assembly|
|regulation of defense response|
|regulation of multi-organism process|
|regulation of cellular catabolic process|
|cellular macromolecule catabolic process|
|regulation of catabolic process|
|response to organonitrogen compound|
|endoplasmic reticulum|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|identical protein binding|
|response to nitrogen compound|
|regulation of response to external stimulus|
|negative regulation of molecular function|
|regulation of immune response|
|response to abiotic stimulus|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|proteolysis|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of response to stress|
|regulation of apoptotic process|
|regulation of programmed cell death|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|regulation of immune system process|
|regulation of cell death|
|cellular response to stress|
|positive regulation of protein metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|-1.86|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|1.71|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|1.74|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|1.8|
|[[:results:exp275|Citral 75μM R06 exp275]]|1.83|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|1.93|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|1.95|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|1.99|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|2|
|[[:results:exp59|UMK57 1μM R01 exp59]]|2|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|2.03|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.05|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2.1|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.13|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|2.18|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|2.19|
|[[:results:exp539|42°C R08 exp539]]|2.24|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|2.33|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|2.49|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|2.51|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2.62|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.64|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|2.72|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|2.76|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|2.87|
|[[:results:exp211|AICAR 240μM R05 exp211]]|2.92|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|2.95|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|2.98|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|3.07|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|3.14|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|3.17|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|3.19|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|3.35|
|[[:results:exp116|AICAR 240μM R03 exp116]]|3.43|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|3.48|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|3.7|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|3.78|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|3.87|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|4|
|[[:results:exp134|MS023 2μM R03 exp134]]|4.01|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|4.09|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|4.23|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|4.33|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|4.38|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|4.94|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|5.17|
|[[:results:exp135|MS023 7μM R03 exp135]]|6.33|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|6.9|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|6.91|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:b:bak1|BAK1]]|0.781|
|[[:human genes:m:march5|MARCH5]]|0.755|
|[[:human genes:p:plaa|PLAA]]|0.741|
|[[:human genes:v:vdac2|VDAC2]]|0.741|
|[[:human genes:a:apaf1|APAF1]]|0.726|
|[[:human genes:c:casp9|CASP9]]|0.712|
|[[:human genes:f:faf2|FAF2]]|0.676|
|[[:human genes:s:serf2|SERF2]]|0.66|
|[[:human genes:c:cycs|CYCS]]|0.628|
|[[:human genes:h:hccs|HCCS]]|0.611|
|[[:human genes:d:diablo|DIABLO]]|0.595|
|[[:human genes:d:dohh|DOHH]]|0.581|
|[[:human genes:e:eny2|ENY2]]|0.553|
|[[:human genes:m:mfn1|MFN1]]|0.553|
|[[:human genes:h:hspd1|HSPD1]]|0.542|
|[[:human genes:a:atad1|ATAD1]]|0.538|
|[[:human genes:g:gfpt1|GFPT1]]|0.523|
|[[:human genes:s:stau1|STAU1]]|0.522|
|[[:human genes:t:thg1l|THG1L]]|0.514|
|[[:human genes:g:gabpa|GABPA]]|0.499|
|[[:human genes:u:uap1|UAP1]]|0.491|
|[[:human genes:b:bap1|BAP1]]|0.487|
|[[:human genes:r:rptor|RPTOR]]|0.486|
|[[:human genes:z:zzz3|ZZZ3]]|0.486|
|[[:human genes:m:mtor|MTOR]]|0.478|
|[[:human genes:r:rad23b|RAD23B]]|0.475|
|[[:human genes:g:gmppb|GMPPB]]|0.474|
|[[:human genes:r:romo1|ROMO1]]|0.466|
|[[:human genes:t:triap1|TRIAP1]]|0.466|
|[[:human genes:d:ddhd2|DDHD2]]|0.458|
|[[:human genes:h:hars|HARS]]|0.458|
|[[:human genes:u:ube2k|UBE2K]]|0.453|
|[[:human genes:m:meaf6|MEAF6]]|0.44|
|[[:human genes:k:kdsr|KDSR]]|0.434|
|[[:human genes:u:ube2g2|UBE2G2]]|0.429|
|[[:human genes:g:gtf3a|GTF3A]]|0.427|
|[[:human genes:t:trim28|TRIM28]]|0.426|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.426|
|[[:human genes:c:cul3|CUL3]]|0.426|
|[[:human genes:t:tada2a|TADA2A]]|0.424|
|[[:human genes:n:nae1|NAE1]]|0.424|
|[[:human genes:m:mlst8|MLST8]]|0.424|
|[[:human genes:n:nudc|NUDC]]|0.422|
|[[:human genes:n:nxt1|NXT1]]|0.421|
|[[:human genes:n:nsd1|NSD1]]|0.417|
|[[:human genes:m:metap2|METAP2]]|0.415|
|[[:human genes:v:vhl|VHL]]|0.414|
|[[:human genes:d:dpagt1|DPAGT1]]|0.409|
|[[:human genes:b:bptf|BPTF]]|0.407|
|[[:human genes:p:pmm2|PMM2]]|0.406|
|[[:human genes:r:rnmt|RNMT]]|0.405|
|[[:human genes:g:gnas|GNAS]]|0.405|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.403|
|[[:human genes:s:sec16a|SEC16A]]|0.401|
|[[:human genes:a:atp5j|ATP5J]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17571
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.4 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UBQLN1 Expression in NALM6 Cells: 7.4'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>