UCN3 [The Human Chemical-Genetic Interaction Map Project]

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======= UCN3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UCN3
  * **<color #00a2e8>Official Name</color>**: urocortin 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=114131|114131]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q969E3|Q969E3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UCN3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UCN3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605901|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|UCN2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|corticotropin-releasing hormone receptor binding|
|corticotropin-releasing hormone receptor 2 binding|
|varicosity|
|positive regulation of membrane potential|
|response to corticosterone|
|response to immobilization stress|
|response to mineralocorticoid|
|axon terminus|
|positive regulation of insulin secretion|
|positive regulation of peptide hormone secretion|
|hormone activity|
|digestion|
|positive regulation of hormone secretion|
|adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|response to glucose|
|response to hexose|
|response to glucocorticoid|
|cAMP-mediated signaling|
|response to monosaccharide|
|response to corticosteroid|
|hormone-mediated signaling pathway|
|cyclic-nucleotide-mediated signaling|
|response to carbohydrate|
|regulation of insulin secretion|
|cellular response to hypoxia|
|response to starvation|
|response to ketone|
|cellular response to decreased oxygen levels|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|regulation of peptide hormone secretion|
|cellular response to oxygen levels|
|response to alcohol|
|cellular response to nutrient levels|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|cellular response to extracellular stimulus|
|regulation of hormone secretion|
|positive regulation of protein secretion|
|positive regulation of peptide secretion|
|response to steroid hormone|
|cellular response to external stimulus|
|second-messenger-mediated signaling|
|response to hypoxia|
|response to decreased oxygen levels|
|response to oxygen levels|
|positive regulation of secretion by cell|
|positive regulation of protein transport|
|regulation of membrane potential|
|positive regulation of secretion|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|regulation of peptide secretion|
|response to nutrient levels|
|response to extracellular stimulus|
|regulation of hormone levels|
|cellular response to hormone stimulus|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of secretion|
|response to lipid|
|response to hormone|
|response to organic cyclic compound|
|positive regulation of transport|
|regulation of protein localization|
|response to abiotic stimulus|
|cellular response to endogenous stimulus|
|G protein-coupled receptor signaling pathway|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|extracellular space|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of transport|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp390|Pifithrin-alpha 20μM R07 exp390]]|1.76|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|1.78|
|[[:results:exp314|Dimethyloxaloylglycine 11μM R07 exp314]]|1.83|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|1.84|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|1.9|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.05|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|2.31|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9992
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.79 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UCN3 Expression in NALM6 Cells: -4.79'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>