UCP1 [The Human Chemical-Genetic Interaction Map Project]

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======= UCP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UCP1
  * **<color #00a2e8>Official Name</color>**: uncoupling protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7350|7350]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P25874|P25874]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UCP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UCP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/113730|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Mitochondrial uncoupling proteins (UCP) are members of the family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed only in brown adipose tissue, a specialized tissue which functions to produce heat. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates to non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance (By similarity). Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane (PubMed:24196960). However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Regulates the production of reactive oxygen species/ROS by mitochondria (By similarity). {ECO:0000250|UniProtKB:P12242, ECO:0000269|PubMed:24196960}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Mito carr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|purine ribonucleotide binding|
|oxidative phosphorylation uncoupler activity|
|long-chain fatty acid binding|
|cardiolipin binding|
|diet induced thermogenesis|
|adaptive thermogenesis|
|response to dietary excess|
|brown fat cell differentiation|
|response to cold|
|cellular response to fatty acid|
|transmembrane transporter activity|
|response to fatty acid|
|regulation of reactive oxygen species biosynthetic process|
|mitochondrial transmembrane transport|
|positive regulation of cold-induced thermogenesis|
|fat cell differentiation|
|cellular response to reactive oxygen species|
|proton transmembrane transport|
|regulation of cold-induced thermogenesis|
|response to temperature stimulus|
|regulation of reactive oxygen species metabolic process|
|response to reactive oxygen species|
|cellular response to acid chemical|
|mitochondrial transport|
|cellular response to oxidative stress|
|response to acid chemical|
|response to oxidative stress|
|mitochondrial inner membrane|
|monovalent inorganic cation transport|
|response to nutrient levels|
|cellular response to lipid|
|response to extracellular stimulus|
|inorganic cation transmembrane transport|
|cellular response to hormone stimulus|
|cation transmembrane transport|
|inorganic ion transmembrane transport|
|cation transport|
|response to lipid|
|response to hormone|
|ion transmembrane transport|
|cellular response to oxygen-containing compound|
|response to abiotic stimulus|
|cellular response to endogenous stimulus|
|mitochondrion|
|transmembrane transport|
|ion transport|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|cellular response to stress|
|positive regulation of multicellular organismal process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10350
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UCP1 Expression in NALM6 Cells: -4.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>