UCP3 [The Human Chemical-Genetic Interaction Map Project]

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======= UCP3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UCP3
  * **<color #00a2e8>Official Name</color>**: uncoupling protein 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7352|7352]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P55916|P55916]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UCP3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UCP3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602044|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. The different UCPs have tissue-specific expression; this gene is primarily expressed in skeletal muscle. This gene's protein product is postulated to protect mitochondria against lipid-induced oxidative stress. Expression levels of this gene increase when fatty acid supplies to mitochondria exceed their oxidation capacity and the protein enables the export of fatty acids from mitochondria. UCPs contain the three solcar protein domains typically found in MACPs. Two splice variants have been found for this gene.[provided by RefSeq, Nov 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Mito carr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|oxidative phosphorylation uncoupler activity|
|response to superoxide|
|response to oxygen radical|
|adaptive thermogenesis|
|transporter activity|
|respiratory gaseous exchange by respiratory system|
|response to cold|
|response to activity|
|mitochondrial transmembrane transport|
|proton transmembrane transport|
|response to glucocorticoid|
|response to corticosteroid|
|response to temperature stimulus|
|response to reactive oxygen species|
|mitochondrial transport|
|response to nutrient|
|response to insulin|
|aging|
|fatty acid metabolic process|
|response to steroid hormone|
|response to hypoxia|
|response to decreased oxygen levels|
|response to oxygen levels|
|response to oxidative stress|
|response to peptide hormone|
|mitochondrial inner membrane|
|monovalent inorganic cation transport|
|response to peptide|
|response to nutrient levels|
|monocarboxylic acid metabolic process|
|response to extracellular stimulus|
|response to inorganic substance|
|inorganic cation transmembrane transport|
|cellular response to hormone stimulus|
|cation transmembrane transport|
|inorganic ion transmembrane transport|
|cation transport|
|response to lipid|
|response to hormone|
|carboxylic acid metabolic process|
|response to organic cyclic compound|
|ion transmembrane transport|
|cellular lipid metabolic process|
|response to organonitrogen compound|
|oxoacid metabolic process|
|organic acid metabolic process|
|response to nitrogen compound|
|response to abiotic stimulus|
|lipid metabolic process|
|cellular response to endogenous stimulus|
|mitochondrion|
|transmembrane transport|
|ion transport|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|-1.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.428|
|[[:human genes:r:rrm1|RRM1]]|0.415|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18511
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.69 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UCP3 Expression in NALM6 Cells: 1.69'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>