UFC1 [The Human Chemical-Genetic Interaction Map Project]

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======= UFC1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UFC1
  * **<color #00a2e8>Official Name</color>**: ubiquitin-fold modifier conjugating enzyme 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51506|51506]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y3C8|Q9Y3C8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UFC1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UFC1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610554|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage. {ECO:0000269|PubMed:15071506}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|UFC1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|UFM1 transferase activity|
|protein K69-linked ufmylation|
|protein polyufmylation|
|protein ufmylation|
|response to endoplasmic reticulum stress|
|brain development|
|protein modification by small protein conjugation|
|head development|
|central nervous system development|
|protein modification by small protein conjugation or removal|
|cellular response to stress|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-3.16|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-2.7|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|-2.41|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-2.13|
|[[:results:exp462|Cadmium 60μM R08 exp462]]|-2.11|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|-1.88|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-1.83|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-1.79|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|-1.77|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|-1.75|
|[[:results:exp136|MS094 2μM R03 exp136]]|-1.71|
|[[:results:exp100|NFN1 1μM R03 exp100]]|1.7|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|1.8|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|1.81|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|1.85|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|1.89|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|1.91|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|1.95|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|1.95|
|[[:results:exp135|MS023 7μM R03 exp135]]|2|
|[[:results:exp116|AICAR 240μM R03 exp116]]|2.03|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|2.07|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|2.12|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|2.16|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|2.17|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|2.26|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|2.63|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:c1orf27|C1orf27]]|0.767|
|[[:human genes:u:ufsp2|UFSP2]]|0.731|
|[[:human genes:u:ufm1|UFM1]]|0.718|
|[[:human genes:u:uba5|UBA5]]|0.688|
|[[:human genes:u:ufl1|UFL1]]|0.606|
|[[:human genes:d:ddrgk1|DDRGK1]]|0.532|
|[[:human genes:u:ube2j1|UBE2J1]]|0.523|
|[[:human genes:s:sec62|SEC62]]|0.492|
|[[:human genes:d:dnajb11|DNAJB11]]|0.484|
|[[:human genes:t:tmed10|TMED10]]|0.476|
|[[:human genes:u:ube2g2|UBE2G2]]|0.47|
|[[:human genes:a:alg6|ALG6]]|0.462|
|[[:human genes:a:alg8|ALG8]]|0.439|
|[[:human genes:d:dnajc3|DNAJC3]]|0.435|
|[[:human genes:s:sbds|SBDS]]|0.435|
|[[:human genes:m:manf|MANF]]|0.424|
|[[:human genes:s:sec63|SEC63]]|0.413|
|[[:human genes:a:alg5|ALG5]]|0.411|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.411|
|[[:human genes:d:dhrsx|DHRSX]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7403
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.84 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UFC1 Expression in NALM6 Cells: 5.84'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>