UFM1 [The Human Chemical-Genetic Interaction Map Project]

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======= UFM1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UFM1
  * **<color #00a2e8>Official Name</color>**: ubiquitin fold modifier 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51569|51569]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P61960|P61960]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UFM1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UFM1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610553|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to substrate proteins as a monomer or a lysine-linked polymer. The so-called ufmylation, requires the UFM1-activating E1 enzyme UBA5, the UFM1-conjugating E2 enzyme UFC1, and the UFM1-ligase E3 enzyme UFL1 (PubMed:15071506, PubMed:20018847). This post-translational modification on lysine residues of proteins may play a crucial role in a number of cellular processes. TRIP4 ufmylation may for instance play a role in nuclear receptors-mediated transcription (PubMed:25219498). Other substrates may include DDRGK1 with which it may play a role in the cellular response to endoplasmic reticulum stress (Probable). {ECO:0000269|PubMed:15071506, ECO:0000269|PubMed:20018847, ECO:0000269|PubMed:25219498, ECO:0000305|PubMed:23152784}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ufm1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein polyufmylation|
|protein K69-linked ufmylation|
|protein ufmylation|
|regulation of intracellular estrogen receptor signaling pathway|
|regulation of intracellular steroid hormone receptor signaling pathway|
|response to endoplasmic reticulum stress|
|brain development|
|protein modification by small protein conjugation|
|head development|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|central nervous system development|
|protein modification by small protein conjugation or removal|
|negative regulation of cell death|
|endoplasmic reticulum|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of cell death|
|cellular response to stress|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-2.33|
|[[:results:exp277|Curcumin 6.5μM R06 exp277]]|-1.81|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-1.71|
|[[:results:exp275|Citral 75μM R06 exp275]]|1.84|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|1.85|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|1.89|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|2.35|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:c1orf27|C1orf27]]|0.745|
|[[:human genes:u:ufc1|UFC1]]|0.718|
|[[:human genes:u:uba5|UBA5]]|0.703|
|[[:human genes:u:ufsp2|UFSP2]]|0.683|
|[[:human genes:u:ufl1|UFL1]]|0.599|
|[[:human genes:u:ube2j1|UBE2J1]]|0.554|
|[[:human genes:d:ddrgk1|DDRGK1]]|0.527|
|[[:human genes:d:dnajc3|DNAJC3]]|0.502|
|[[:human genes:d:dnajb11|DNAJB11]]|0.496|
|[[:human genes:u:ube2g2|UBE2G2]]|0.486|
|[[:human genes:m:manf|MANF]]|0.47|
|[[:human genes:a:alg5|ALG5]]|0.465|
|[[:human genes:d:derl1|DERL1]]|0.464|
|[[:human genes:a:alg6|ALG6]]|0.44|
|[[:human genes:t:tmed10|TMED10]]|0.432|
|[[:human genes:k:kiaa0922|KIAA0922]]|0.431|
|[[:human genes:c:ctdnep1|CTDNEP1]]|0.425|
|[[:human genes:p:p4hb|P4HB]]|0.42|
|[[:human genes:a:atp5o|ATP5O]]|0.42|
|[[:human genes:a:atp5j|ATP5J]]|0.411|
|[[:human genes:s:sec63|SEC63]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 301/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|16/28|
|blood|11/28|
|bone|10/26|
|breast|8/33|
|central nervous system|27/56|
|cervix|0/4|
|colorectal|8/17|
|esophagus|4/13|
|fibroblast|1/1|
|gastric|8/16|
|kidney|13/21|
|liver|13/20|
|lung|27/75|
|lymphocyte|2/16|
|ovary|13/26|
|pancreas|10/24|
|peripheral nervous system|0/16|
|plasma cell|13/15|
|prostate|0/1|
|skin|10/24|
|soft tissue|1/9|
|thyroid|2/2|
|upper aerodigestive|9/22|
|urinary tract|13/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9623
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.98 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UFM1 Expression in NALM6 Cells: 5.98'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>