UGGT2 [The Human Chemical-Genetic Interaction Map Project]

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======= UGGT2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UGGT2
  * **<color #00a2e8>Official Name</color>**: UDP-glucose glycoprotein glucosyltransferase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55757|55757]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NYU1|Q9NYU1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UGGT2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UGGT2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605898|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Glyco transf 8|
|UDP-g GGTase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|UDP-glucose:glycoprotein glucosyltransferase activity|
|UDP-glucosylation|
|UDP-glucose metabolic process|
|ER-associated misfolded protein catabolic process|
|endoplasmic reticulum mannose trimming|
|protein demannosylation|
|protein alpha-1,2-demannosylation|
|endoplasmic reticulum quality control compartment|
|cellular response to misfolded protein|
|response to misfolded protein|
|protein quality control for misfolded or incompletely synthesized proteins|
|protein deglycosylation|
|protein N-linked glycosylation via asparagine|
|peptidyl-asparagine modification|
|nucleotide-sugar metabolic process|
|endoplasmic reticulum-Golgi intermediate compartment|
|protein N-linked glycosylation|
|ERAD pathway|
|unfolded protein binding|
|cellular response to topologically incorrect protein|
|response to topologically incorrect protein|
|response to endoplasmic reticulum stress|
|macromolecule glycosylation|
|protein glycosylation|
|glycosylation|
|endoplasmic reticulum lumen|
|glycoprotein biosynthetic process|
|proteasomal protein catabolic process|
|glycoprotein metabolic process|
|nucleobase-containing small molecule metabolic process|
|proteolysis involved in cellular protein catabolic process|
|protein-containing complex|
|cellular protein catabolic process|
|carbohydrate derivative biosynthetic process|
|protein catabolic process|
|peptidyl-amino acid modification|
|cellular macromolecule catabolic process|
|response to organonitrogen compound|
|endoplasmic reticulum|
|carbohydrate derivative metabolic process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|response to nitrogen compound|
|proteolysis|
|organonitrogen compound biosynthetic process|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15938
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.69 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UGGT2 Expression in NALM6 Cells: 1.69'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>