UGP2 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= UGP2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UGP2
  * **<color #00a2e8>Official Name</color>**: UDP-glucose pyrophosphorylase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7360|7360]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q16851|Q16851]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UGP2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UGP2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/191760|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a central role as a glucosyl donor in cellular metabolic pathways.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|UDPGP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|UTP:glucose-1-phosphate uridylyltransferase activity|
|pyrimidine ribonucleotide binding|
|glucose 1-phosphate metabolic process|
|UDP-glucuronate biosynthetic process|
|UDP-glucuronate metabolic process|
|UDP-glucose metabolic process|
|glucose binding|
|glucan biosynthetic process|
|glycogen biosynthetic process|
|nucleotide-sugar biosynthetic process|
|nucleotide-sugar metabolic process|
|polysaccharide biosynthetic process|
|cellular polysaccharide biosynthetic process|
|glycogen metabolic process|
|glucan metabolic process|
|cellular glucan metabolic process|
|cellular carbohydrate biosynthetic process|
|energy reserve metabolic process|
|cellular polysaccharide metabolic process|
|polysaccharide metabolic process|
|carbohydrate biosynthetic process|
|cellular carbohydrate metabolic process|
|energy derivation by oxidation of organic compounds|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|generation of precursor metabolites and energy|
|carbohydrate metabolic process|
|nucleobase-containing small molecule metabolic process|
|small molecule biosynthetic process|
|carbohydrate derivative biosynthetic process|
|organophosphate metabolic process|
|carboxylic acid metabolic process|
|oxidation-reduction process|
|oxoacid metabolic process|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|identical protein binding|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|1.75|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|1.78|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|1.84|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|1.87|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|1.89|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|1.97|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|2.28|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|2.38|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|2.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pgm3|PGM3]]|0.443|
|[[:human genes:p:pmvk|PMVK]]|0.417|
|[[:human genes:d:dhrsx|DHRSX]]|0.409|
|[[:human genes:d:dpm3|DPM3]]|0.407|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 4/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1120
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.49 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UGP2 Expression in NALM6 Cells: 6.49'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>