UGT1A1 [The Human Chemical-Genetic Interaction Map Project]

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======= UGT1A1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: N/A
  * **<color #00a2e8>Official Name</color>**: N/A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54658|54658]]
  * **<color #00a2e8>UniProt</color>**: N/A
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UGT1A1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UGT1A1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Glyco tran 28 C|
|UDPGT|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|biphenyl catabolic process|
|bilirubin conjugation|
|cytochrome complex|
|biphenyl metabolic process|
|flavone metabolic process|
|heme catabolic process|
|porphyrin-containing compound catabolic process|
|pigment catabolic process|
|tetrapyrrole catabolic process|
|flavonoid glucuronidation|
|xenobiotic glucuronidation|
|endoplasmic reticulum chaperone complex|
|xenobiotic catabolic process|
|cellular response to ethanol|
|flavonoid metabolic process|
|cellular glucuronidation|
|UDP-glycosyltransferase activity|
|uronic acid metabolic process|
|glucuronate metabolic process|
|negative regulation of steroid metabolic process|
|benzene-containing compound metabolic process|
|retinoic acid binding|
|glucuronosyltransferase activity|
|steroid binding|
|heme metabolic process|
|enzyme inhibitor activity|
|retinoic acid metabolic process|
|estrogen metabolic process|
|cellular response to estradiol stimulus|
|porphyrin-containing compound metabolic process|
|acute-phase response|
|antibiotic catabolic process|
|cellular response to glucocorticoid stimulus|
|cellular response to corticosteroid stimulus|
|tetrapyrrole metabolic process|
|cofactor catabolic process|
|pigment metabolic process|
|acute inflammatory response|
|animal organ regeneration|
|negative regulation of lipid metabolic process|
|cellular response to alcohol|
|antibiotic metabolic process|
|retinoid metabolic process|
|diterpenoid metabolic process|
|regulation of steroid metabolic process|
|cellular response to antibiotic|
|terpenoid metabolic process|
|cellular hormone metabolic process|
|liver development|
|response to ethanol|
|hepaticobiliary system development|
|xenobiotic metabolic process|
|response to estradiol|
|isoprenoid metabolic process|
|response to glucocorticoid|
|regeneration|
|response to corticosteroid|
|cellular response to xenobiotic stimulus|
|cellular response to steroid hormone stimulus|
|response to starvation|
|monosaccharide metabolic process|
|hormone metabolic process|
|cellular response to toxic substance|
|response to nutrient|
|response to alcohol|
|steroid metabolic process|
|response to xenobiotic stimulus|
|response to antibiotic|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|response to steroid hormone|
|enzyme binding|
|regulation of lipid metabolic process|
|cellular response to drug|
|gland development|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|cofactor metabolic process|
|aromatic compound catabolic process|
|carbohydrate metabolic process|
|organic cyclic compound catabolic process|
|protein heterodimerization activity|
|inflammatory response|
|response to nutrient levels|
|drug metabolic process|
|response to toxic substance|
|cellular response to lipid|
|monocarboxylic acid metabolic process|
|response to extracellular stimulus|
|regulation of hormone levels|
|cellular response to organic cyclic compound|
|cellular response to hormone stimulus|
|intracellular membrane-bounded organelle|
|response to bacterium|
|negative regulation of catalytic activity|
|response to lipid|
|protein homodimerization activity|
|response to hormone|
|carboxylic acid metabolic process|
|response to organic cyclic compound|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|oxoacid metabolic process|
|endoplasmic reticulum|
|response to drug|
|organic acid metabolic process|
|cellular response to oxygen-containing compound|
|organonitrogen compound catabolic process|
|negative regulation of molecular function|
|lipid metabolic process|
|cellular response to endogenous stimulus|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|integral component of plasma membrane|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp59|UMK57 1μM R01 exp59]]|-1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9937
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.58 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UGT1A1 Expression in NALM6 Cells: 1.58'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>