ULK1 [The Human Chemical-Genetic Interaction Map Project]

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======= ULK1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ULK1
  * **<color #00a2e8>Official Name</color>**: unc-51 like autophagy activating kinase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8408|8408]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75385|O75385]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ULK1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ULK1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603168|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3- kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation. May also phosphorylate SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165). {ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:21460634, ECO:0000269|PubMed:21795849, ECO:0000269|PubMed:25040165}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF3543|
|Pkinase|
|Pkinase Tyr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|extrinsic component of autophagosome membrane|
|extrinsic component of phagophore assembly site membrane|
|extrinsic component of omegasome membrane|
|positive regulation by symbiont of host autophagy|
|modulation by symbiont of host autophagy|
|Atg1/ULK1 kinase complex|
|positive regulation of autophagosome assembly|
|guanyl-nucleotide exchange factor complex|
|positive regulation of vacuole organization|
|phagophore assembly site membrane|
|phagophore assembly site|
|modulation by symbiont of host cellular process|
|neuron projection regeneration|
|GTPase binding|
|axon extension|
|regulation of autophagosome assembly|
|modification by symbiont of host morphology or physiology|
|regulation of vacuole organization|
|neuron projection extension|
|autophagosome assembly|
|autophagosome organization|
|positive regulation of macroautophagy|
|autophagosome|
|positive regulation of organelle assembly|
|kinase activity|
|peptidyl-threonine phosphorylation|
|developmental cell growth|
|cell growth|
|peptidyl-threonine modification|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|developmental growth involved in morphogenesis|
|recycling endosome|
|positive regulation of autophagy|
|vacuole organization|
|negative regulation of protein complex assembly|
|Rab GTPase binding|
|modification of morphology or physiology of other organism|
|regeneration|
|interaction with host|
|macroautophagy|
|mitochondrial outer membrane|
|regulation of macroautophagy|
|peptidyl-serine phosphorylation|
|protein autophosphorylation|
|response to starvation|
|peptidyl-serine modification|
|regulation of organelle assembly|
|cellular response to nutrient levels|
|process utilizing autophagic mechanism|
|autophagy|
|cellular response to extracellular stimulus|
|protein-containing complex binding|
|axon|
|regulation of autophagy|
|cellular response to external stimulus|
|protein serine/threonine kinase activity|
|positive regulation of cellular catabolic process|
|axonogenesis|
|developmental growth|
|growth|
|axon development|
|positive regulation of catabolic process|
|cell morphogenesis involved in neuron differentiation|
|regulation of protein complex assembly|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|response to nutrient levels|
|cell part morphogenesis|
|positive regulation of cellular component biogenesis|
|response to extracellular stimulus|
|cell morphogenesis involved in differentiation|
|positive regulation of organelle organization|
|neuron projection development|
|negative regulation of cellular component organization|
|cell morphogenesis|
|organelle assembly|
|symbiotic process|
|neuron development|
|interspecies interaction between organisms|
|cellular component morphogenesis|
|regulation of cellular catabolic process|
|peptidyl-amino acid modification|
|endoplasmic reticulum membrane|
|regulation of cellular component biogenesis|
|protein phosphorylation|
|regulation of catabolic process|
|neuron differentiation|
|identical protein binding|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|positive regulation of cellular component organization|
|phosphorylation|
|regulation of organelle organization|
|ATP binding|
|generation of neurons|
|neurogenesis|
|cell development|
|cellular response to stress|
|cellular catabolic process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp303|39°C R06 exp303]]|-1.94|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.43|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7325
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.45 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ULK1 Expression in NALM6 Cells: 4.45'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>