ULK2 [The Human Chemical-Genetic Interaction Map Project]

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======= ULK2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ULK2
  * **<color #00a2e8>Official Name</color>**: unc-51 like autophagy activating kinase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9706|9706]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8IYT8|Q8IYT8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ULK2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ULK2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608650|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that is similar to a serine/threonine kinase in C. elegans which is involved in axonal elongation. The structure of this protein is similar to the C. elegans protein in that both proteins have an N-terminal kinase domain, a central proline/serine rich (PS) domain, and a C-terminal (C) domain. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Dec 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3- kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR; however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons. {ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:21460634, ECO:0000269|PubMed:21460635, ECO:0000269|PubMed:21690395, ECO:0000269|PubMed:21795849}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase|
|Pkinase Tyr|
|DUF3543|
|Kdo|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation by symbiont of host autophagy|
|modulation by symbiont of host autophagy|
|negative regulation of collateral sprouting|
|phagophore assembly site membrane|
|regulation of collateral sprouting|
|phagophore assembly site|
|modulation by symbiont of host cellular process|
|axon extension|
|modification by symbiont of host morphology or physiology|
|neuron projection extension|
|autophagosome assembly|
|autophagosome organization|
|negative regulation of axonogenesis|
|developmental cell growth|
|cell growth|
|negative regulation of cell morphogenesis involved in differentiation|
|negative regulation of developmental growth|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|regulation of extent of cell growth|
|developmental growth involved in morphogenesis|
|positive regulation of autophagy|
|vacuole organization|
|cytoplasmic vesicle membrane|
|negative regulation of neuron projection development|
|modification of morphology or physiology of other organism|
|interaction with host|
|macroautophagy|
|negative regulation of cell projection organization|
|regulation of cell size|
|negative regulation of cell growth|
|regulation of axonogenesis|
|response to starvation|
|protein autophosphorylation|
|negative regulation of neuron differentiation|
|negative regulation of growth|
|autophagy|
|process utilizing autophagic mechanism|
|negative regulation of neurogenesis|
|regulation of cell morphogenesis involved in differentiation|
|negative regulation of nervous system development|
|regulation of developmental growth|
|regulation of autophagy|
|negative regulation of cell development|
|protein serine/threonine kinase activity|
|positive regulation of cellular catabolic process|
|axonogenesis|
|regulation of cellular component size|
|developmental growth|
|growth|
|axon development|
|regulation of cell growth|
|cell morphogenesis involved in neuron differentiation|
|positive regulation of catabolic process|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|regulation of cell morphogenesis|
|cell projection morphogenesis|
|regulation of neuron projection development|
|response to nutrient levels|
|cell part morphogenesis|
|regulation of anatomical structure size|
|response to extracellular stimulus|
|cell morphogenesis involved in differentiation|
|regulation of neuron differentiation|
|neuron projection development|
|regulation of growth|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|cell morphogenesis|
|organelle assembly|
|symbiotic process|
|neuron development|
|regulation of neurogenesis|
|interspecies interaction between organisms|
|cellular component morphogenesis|
|regulation of cellular catabolic process|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|protein phosphorylation|
|regulation of catabolic process|
|neuron differentiation|
|regulation of anatomical structure morphogenesis|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|negative regulation of multicellular organismal process|
|phosphorylation|
|ATP binding|
|generation of neurons|
|neurogenesis|
|cell development|
|cellular catabolic process|
|regulation of cell differentiation|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp151|SGC0946 7μM R03 exp151]]|1.84|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|1.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14064
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ULK2 Expression in NALM6 Cells: 3.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>