UPP2 [The Human Chemical-Genetic Interaction Map Project]

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======= UPP2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UPP2
  * **<color #00a2e8>Official Name</color>**: uridine phosphorylase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=151531|151531]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95045|O95045]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UPP2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UPP2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617340|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Shows substrate specificity and accept uridine, deoxyuridine, and thymidine as well as the two pyrimidine nucleoside analogs 5-fluorouridine and 5-fluoro-2(')-deoxyuridine as substrates.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PNP UDP 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|uridine phosphorylase activity|
|uridine metabolic process|
|type III intermediate filament|
|UMP salvage|
|pyrimidine nucleotide salvage|
|pyrimidine ribonucleotide salvage|
|pyrimidine ribonucleoside monophosphate metabolic process|
|UMP metabolic process|
|UMP biosynthetic process|
|pyrimidine ribonucleoside monophosphate biosynthetic process|
|pyrimidine nucleoside salvage|
|pyrimidine-containing compound salvage|
|pyrimidine ribonucleoside metabolic process|
|nucleotide salvage|
|pyrimidine nucleoside monophosphate biosynthetic process|
|nucleoside salvage|
|pyrimidine nucleoside biosynthetic process|
|pyrimidine nucleoside monophosphate metabolic process|
|pyrimidine ribonucleotide biosynthetic process|
|pyrimidine nucleoside catabolic process|
|pyrimidine ribonucleotide metabolic process|
|ribonucleoside monophosphate biosynthetic process|
|nucleoside catabolic process|
|cellular metabolic compound salvage|
|pyrimidine nucleoside metabolic process|
|nucleoside biosynthetic process|
|glycosyl compound biosynthetic process|
|nucleoside monophosphate biosynthetic process|
|pyrimidine-containing compound catabolic process|
|glycosyl compound catabolic process|
|pyrimidine nucleotide biosynthetic process|
|nucleobase-containing small molecule catabolic process|
|ribonucleoside monophosphate metabolic process|
|pyrimidine-containing compound biosynthetic process|
|pyrimidine nucleotide metabolic process|
|nucleotide catabolic process|
|nucleoside phosphate catabolic process|
|nucleoside monophosphate metabolic process|
|ribonucleoside metabolic process|
|pyrimidine-containing compound metabolic process|
|nucleobase-containing small molecule biosynthetic process|
|nucleoside metabolic process|
|organophosphate catabolic process|
|glycosyl compound metabolic process|
|ribonucleotide biosynthetic process|
|ribose phosphate biosynthetic process|
|carbohydrate derivative catabolic process|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|ribonucleotide metabolic process|
|ribose phosphate metabolic process|
|nucleobase-containing compound catabolic process|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|small molecule catabolic process|
|aromatic compound catabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|organic cyclic compound catabolic process|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|small molecule biosynthetic process|
|carbohydrate derivative biosynthetic process|
|organophosphate metabolic process|
|carbohydrate derivative metabolic process|
|organonitrogen compound catabolic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16946
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.16 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UPP2 Expression in NALM6 Cells: -1.16'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>