UQCRFS1 [The Human Chemical-Genetic Interaction Map Project]

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======= UQCRFS1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UQCRFS1
  * **<color #00a2e8>Official Name</color>**: ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7386|7386]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P47985|P47985]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UQCRFS1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UQCRFS1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/191327|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Cytochrome b-c1 complex subunit Rieske, mitochondrial: Component of the mitochondrial ubiquinol-cytochrome c reductase complex dimer (complex III dimer), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (PubMed:28673544). Incorporation of UQCRFS1 is the penultimate step in complex III assembly (By similarity). {ECO:0000250|UniProtKB:P47985, ECO:0000269|PubMed:28673544}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|UCR TM|
|Ubiq-Cytc-red N|
|Rieske|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ubiquinol-cytochrome-c reductase activity|
|mitochondrial respiratory chain complex IV|
|mitochondrial respiratory chain complex III|
|mitochondrial electron transport, ubiquinol to cytochrome c|
|2 iron, 2 sulfur cluster binding|
|mitochondrial ATP synthesis coupled electron transport|
|ATP synthesis coupled electron transport|
|respiratory electron transport chain|
|oxidative phosphorylation|
|cellular respiration|
|electron transport chain|
|ATP metabolic process|
|energy derivation by oxidation of organic compounds|
|mitochondrial inner membrane|
|generation of precursor metabolites and energy|
|oxidation-reduction process|
|mitochondrion|
|phosphorylation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|1.7|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:u:uqcrc2|UQCRC2]]|0.502|
|[[:human genes:u:uqcrc1|UQCRC1]]|0.445|
|[[:human genes:m:mrps34|MRPS34]]|0.414|
|[[:human genes:m:mrpl55|MRPL55]]|0.409|
|[[:human genes:u:uqcr10|UQCR10]]|0.407|
|[[:human genes:m:mrps2|MRPS2]]|0.403|
|[[:human genes:c:cox6b1|COX6B1]]|0.402|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 110/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|5/28|
|blood|7/28|
|bone|1/26|
|breast|7/33|
|central nervous system|1/56|
|cervix|1/4|
|colorectal|3/17|
|esophagus|3/13|
|fibroblast|0/1|
|gastric|3/16|
|kidney|2/21|
|liver|6/20|
|lung|19/75|
|lymphocyte|1/16|
|ovary|2/26|
|pancreas|3/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|6/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|3/22|
|urinary tract|4/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 811
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.34 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UQCRFS1 Expression in NALM6 Cells: 6.34'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>