URGCP [The Human Chemical-Genetic Interaction Map Project]

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======= URGCP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: URGCP
  * **<color #00a2e8>Official Name</color>**: upregulator of cell proliferation
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55665|55665]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8TCY9|Q8TCY9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=URGCP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20URGCP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610337|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May be involved in cell cycle progression through the regulation of cyclin D1 expression. May participate in the development of hepatocellular carcinoma (HCC) by promoting hepatocellular growth and survival. May play an important role in development of gastric cancer. {ECO:0000269|PubMed:12082552, ECO:0000269|PubMed:17217616}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|GTP binding|
|cell cycle|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-2|
|[[:results:exp218|A-395 10μM R05 exp218]]|-1.98|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|-1.98|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|-1.93|
|[[:results:exp121|Golgicide-A 2μM R03 exp121]]|-1.84|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-1.83|
|[[:results:exp123|GSK-LSD1 10μM R03 exp123]]|-1.77|
|[[:results:exp114|A-196 10μM R03 exp114]]|-1.76|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|1.84|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|1.87|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|2.09|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|2.27|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|2.77|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|3.2|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16631
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='URGCP Expression in NALM6 Cells: 5.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>