UROS [The Human Chemical-Genetic Interaction Map Project]

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======= UROS =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UROS
  * **<color #00a2e8>Official Name</color>**: uroporphyrinogen III synthase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7390|7390]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P10746|P10746]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UROS&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UROS|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606938|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene catalyzes the fourth step of porphyrin biosynthesis in the heme biosynthetic pathway. Defects in this gene cause congenital erythropoietic porphyria (Gunther's disease). [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the branch point for the various sub-pathways leading to the wide diversity of porphyrins. Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as methionine synthesis (vitamin B12) or oxygen transport (heme).

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HEM4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|uroporphyrinogen-III synthase activity|
|response to platinum ion|
|uroporphyrinogen III metabolic process|
|cellular response to amine stimulus|
|uroporphyrinogen III biosynthetic process|
|protoporphyrinogen IX biosynthetic process|
|protoporphyrinogen IX metabolic process|
|cofactor binding|
|cellular response to arsenic-containing substance|
|heme biosynthetic process|
|porphyrin-containing compound biosynthetic process|
|tetrapyrrole biosynthetic process|
|heme metabolic process|
|response to arsenic-containing substance|
|porphyrin-containing compound metabolic process|
|response to amine|
|pigment biosynthetic process|
|tetrapyrrole metabolic process|
|pigment metabolic process|
|cofactor biosynthetic process|
|carboxylic acid biosynthetic process|
|response to antibiotic|
|organic acid biosynthetic process|
|response to metal ion|
|cofactor metabolic process|
|response to inorganic substance|
|small molecule biosynthetic process|
|cellular response to organonitrogen compound|
|cellular response to nitrogen compound|
|carboxylic acid metabolic process|
|response to organonitrogen compound|
|oxoacid metabolic process|
|organic acid metabolic process|
|response to nitrogen compound|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|cellular response to endogenous stimulus|
|mitochondrion|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|response to endogenous stimulus|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp133|MKC9989 10μM R03 exp133]]|-2.03|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|-1.85|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|1.73|
|[[:results:exp302|35°C R06 exp302]]|1.75|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|1.76|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|1.76|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|1.8|
|[[:results:exp16|DABN 2μM R00 exp16]]|1.9|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|2.15|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|2.32|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|5.21|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cpox|CPOX]]|0.57|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 912
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.37 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UROS Expression in NALM6 Cells: 5.37'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>