USP17L17 [The Human Chemical-Genetic Interaction Map Project]

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======= USP17L17 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: USP17L17
  * **<color #00a2e8>Official Name</color>**: ubiquitin specific peptidase 17 like family member 17
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=100287327|100287327]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/D6RBQ6|D6RBQ6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=USP17L17&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20USP17L17|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|UCH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cysteine-type endopeptidase activity|
|thiol-dependent ubiquitin-specific protease activity|
|protein deubiquitination|
|protein modification by small protein removal|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|protein catabolic process|
|cellular macromolecule catabolic process|
|protein modification by small protein conjugation or removal|
|endoplasmic reticulum|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|proteolysis|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of cell death|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp262|Alda-1 10μM R06 exp262]]|-3.03|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|-2.3|
|[[:results:exp130|JQ1 0.01μM R03 exp130]]|-2.17|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|-2.17|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-2.15|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|-2.07|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|-2.04|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|-1.96|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|-1.78|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|-1.75|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-1.73|
|[[:results:exp123|GSK-LSD1 10μM R03 exp123]]|-1.72|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|1.7|
|[[:results:exp150|SGC0649 7μM R03 exp150]]|1.71|
|[[:results:exp314|Dimethyloxaloylglycine 11μM R07 exp314]]|1.75|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|1.76|
|[[:results:exp493|IL-3 9ng/ml R08 exp493]]|1.76|
|[[:results:exp124|GSK343 3μM R03 exp124]]|1.81|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|1.82|
|[[:results:exp372|Ibrutinib 1μM R07 exp372]]|1.83|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|1.84|
|[[:results:exp393|Resminostat 0.5μM R07 exp393]]|1.86|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|1.9|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|1.93|
|[[:results:exp516|Pyrazinamide 100μM R08 exp516]]|1.93|
|[[:results:exp318|ABT-702 5μM R07 exp318]]|1.95|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|2.29|
|[[:results:exp425|Beta-Estradiol 0.55μM R07 exp425]]|2.42|
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|2.6|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|2.61|
|[[:results:exp273|Cisplatin 0.35μM R06 exp273]]|2.74|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|2.87|
|[[:results:exp494|Isoniazid 100μM R08 exp494]]|3.14|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6318
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='USP17L17 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>