USP17L19 [The Human Chemical-Genetic Interaction Map Project]

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======= USP17L19 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: USP17L19
  * **<color #00a2e8>Official Name</color>**: ubiquitin specific peptidase 17 like family member 19
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=100287404|100287404]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/D6RCP7|D6RCP7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=USP17L19&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20USP17L19|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|UCH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cysteine-type endopeptidase activity|
|thiol-dependent ubiquitin-specific protease activity|
|protein deubiquitination|
|protein modification by small protein removal|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|protein catabolic process|
|cellular macromolecule catabolic process|
|protein modification by small protein conjugation or removal|
|endoplasmic reticulum|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|proteolysis|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of cell death|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|-2.27|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-2.15|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-2.13|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|-2|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-1.81|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|-1.79|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-1.73|
|[[:results:exp136|MS094 2μM R03 exp136]]|1.74|
|[[:results:exp218|A-395 10μM R05 exp218]]|1.76|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|1.79|
|[[:results:exp148|SB202190 10μM R03 exp148]]|1.8|
|[[:results:exp152|SGC2043 10μM R03 exp152]]|1.85|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|1.87|
|[[:results:exp336|Asunaprenir 3μM R07 exp336]]|1.96|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|1.99|
|[[:results:exp405|Tenofovir 10μM R07 exp405]]|2.02|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|2.03|
|[[:results:exp314|Dimethyloxaloylglycine 11μM R07 exp314]]|2.04|
|[[:results:exp318|ABT-702 5μM R07 exp318]]|2.24|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|2.25|
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|2.26|
|[[:results:exp73|LJH685 5μM R02 exp73]]|2.45|
|[[:results:exp101|Nicotinamide 1000μM R03 exp101]]|2.58|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|2.59|
|[[:results:exp390|Pifithrin-alpha 20μM R07 exp390]]|2.87|
|[[:results:exp392|PT-1 25μM R07 exp392]]|2.97|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3051
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -6.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='USP17L19 Expression in NALM6 Cells: -6.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>