USP48 [The Human Chemical-Genetic Interaction Map Project]

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======= USP48 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: USP48
  * **<color #00a2e8>Official Name</color>**: ubiquitin specific peptidase 48
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84196|84196]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86UV5|Q86UV5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=USP48&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20USP48|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617445|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein containing domains that associate it with the peptidase family C19, also known as family 2 of ubiquitin carboxyl-terminal hydrolases. Family members function as deubiquitinating enzymes, recognizing and hydrolyzing the peptide bond at the C-terminal glycine of ubiquitin. Enzymes in peptidase family C19 are involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|UCH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cysteine-type endopeptidase activity|
|thiol-dependent ubiquitin-specific protease activity|
|protein deubiquitination|
|protein modification by small protein removal|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|protein catabolic process|
|cellular macromolecule catabolic process|
|protein modification by small protein conjugation or removal|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|mitochondrion|
|proteolysis|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp464|Calcipotriol 5μM R08 exp464]]|-2.02|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|-1.99|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|-1.94|
|[[:results:exp279|D-Fructose 10000μM R06 exp279]]|-1.75|
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|-1.73|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|-1.73|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|1.7|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|1.71|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|1.72|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|1.74|
|[[:results:exp261|ABT-702 5μM R06 exp261]]|1.76|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|1.83|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|1.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.54|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4990
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='USP48 Expression in NALM6 Cells: 7.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>