USP9Y [The Human Chemical-Genetic Interaction Map Project]

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======= USP9Y =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: USP9Y
  * **<color #00a2e8>Official Name</color>**: ubiquitin specific peptidase 9 Y-linked
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8287|8287]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O00507|O00507]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=USP9Y&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20USP9Y|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/400005|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of the peptidase C19 family. It encodes a protein that is similar to ubiquitin-specific proteases, which cleave the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. [provided by RefSeq, Mar 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May function as a ubiquitin-protein or polyubiquitin hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Essential component of TGF-beta/BMP signaling cascade. Deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade. Deubiquitination of SMAD4 by USP9X re-empowers its competence to mediate TGF-beta signaling (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|UCH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|co-SMAD binding|
|cysteine-type peptidase activity|
|BMP signaling pathway|
|cysteine-type endopeptidase activity|
|transforming growth factor beta receptor signaling pathway|
|response to BMP|
|cellular response to BMP stimulus|
|thiol-dependent ubiquitin-specific protease activity|
|cellular response to transforming growth factor beta stimulus|
|response to transforming growth factor beta|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|protein deubiquitination|
|protein modification by small protein removal|
|cellular response to growth factor stimulus|
|ubiquitin-dependent protein catabolic process|
|response to growth factor|
|modification-dependent protein catabolic process|
|spermatogenesis|
|modification-dependent macromolecule catabolic process|
|male gamete generation|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|protein catabolic process|
|gamete generation|
|enzyme linked receptor protein signaling pathway|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|cellular macromolecule catabolic process|
|protein modification by small protein conjugation or removal|
|multi-organism reproductive process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|cellular response to endogenous stimulus|
|proteolysis|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17022
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.74 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='USP9Y Expression in NALM6 Cells: 6.74'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>