UVRAG [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= UVRAG =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UVRAG
  * **<color #00a2e8>Official Name</color>**: UV radiation resistance associated
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7405|7405]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9P2Y5|Q9P2Y5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UVRAG&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UVRAG|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602493|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Versatile protein that is involved in regulation of different cellular pathways implicated in membrane trafficking. Involved in regulation of the COPI-dependent retrograde transport from Golgi and the endoplasmic reticulum by associating with the NRZ complex; the function is dependent on its binding to phosphatidylinositol 3-phosphate (PtdIns(3)P) (PubMed:24056303). During autophagy acts as regulatory subunit of the alternative PI3K complex II (PI3KC3-C2) that mediates formation of phosphatidylinositol 3-phosphate and is believed to be involved in maturation of autophagosomes and endocytosis. Activates lipid kinase activity of PIK3C3. Involved in the regulation of degradative endocytic trafficking and cytokinesis, and in regulation of ATG9A transport from the Golgi to the autophagosome; the functions seems to implicate its association with PI3KC3-C2 (PubMed:16799551, PubMed:20643123, PubMed:24056303). Involved in maturation of autophagosomes and degradative endocytic trafficking independently of BECN1 but depending on its association with a class C Vps complex (possibly the HOPS complex); the association is also proposed to promote autophagosome recruitment and activation of Rab7 and endosome-endosome fusion events (PubMed:18552835). Enhances class C Vps complex (possibly HOPS complex) association with a SNARE complex and promotes fusogenic SNARE complex formation during late endocytic membrane fusion (PubMed:24550300). In case of negative-strand RNA virus infection is required for efficient virus entry, promotes endocytic transport of virions and is implicated in a VAMP8-specific fusogenic SNARE complex assembly (PubMed:24550300). {ECO:0000269|PubMed:18552835, ECO:0000269|PubMed:20643123, ECO:0000269|PubMed:24056303, ECO:0000305}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Atg14|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|DNA-dependent protein kinase complex|
|maintenance of Golgi location|
|double-strand break repair via classical nonhomologous end joining|
|positive regulation of autophagosome maturation|
|SNARE complex assembly|
|regulation of autophagosome maturation|
|maintenance of organelle location|
|Golgi localization|
|receptor catabolic process|
|autophagosome maturation|
|autophagosome membrane|
|multivesicular body sorting pathway|
|positive regulation of protein complex disassembly|
|chromosome, centromeric region|
|double-strand break repair via nonhomologous end joining|
|phagocytic vesicle|
|non-recombinational repair|
|SNARE binding|
|positive regulation of macroautophagy|
|vesicle fusion|
|organelle membrane fusion|
|centrosome cycle|
|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|
|regulation of cytokinesis|
|microtubule organizing center organization|
|viral entry into host cell|
|maintenance of location in cell|
|organelle fusion|
|entry into host cell|
|entry into host|
|receptor metabolic process|
|regulation of protein complex disassembly|
|positive regulation of autophagy|
|late endosome|
|membrane fusion|
|SH3 domain binding|
|spindle organization|
|interaction with host|
|midbody|
|macroautophagy|
|maintenance of location|
|regulation of cell division|
|regulation of macroautophagy|
|double-strand break repair|
|viral life cycle|
|protein-containing complex disassembly|
|lysosome|
|early endosome|
|process utilizing autophagic mechanism|
|autophagy|
|chromosome segregation|
|vesicle organization|
|regulation of autophagy|
|positive regulation of cellular catabolic process|
|Golgi vesicle transport|
|cellular component disassembly|
|positive regulation of catabolic process|
|microtubule cytoskeleton organization|
|centrosome|
|DNA repair|
|regulation of protein serine/threonine kinase activity|
|organelle localization|
|positive regulation of organelle organization|
|microtubule-based process|
|viral process|
|DNA metabolic process|
|regulation of cell cycle process|
|cellular response to DNA damage stimulus|
|symbiotic process|
|regulation of protein kinase activity|
|interspecies interaction between organisms|
|regulation of cellular catabolic process|
|cellular protein-containing complex assembly|
|membrane organization|
|regulation of kinase activity|
|regulation of transferase activity|
|regulation of catabolic process|
|cell cycle process|
|endoplasmic reticulum|
|macromolecule catabolic process|
|cytoskeleton organization|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|cell cycle|
|regulation of protein phosphorylation|
|protein-containing complex assembly|
|regulation of phosphorylation|
|cellular response to stress|
|organic substance catabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-2.01|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|-1.92|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-1.85|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-1.84|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|2.04|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|2.05|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.484|
|[[:human genes:l:ldlr|LDLR]]|0.436|
|[[:human genes:h:hars|HARS]]|0.404|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2165
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.12 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UVRAG Expression in NALM6 Cells: 4.12'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>