UXS1 [The Human Chemical-Genetic Interaction Map Project]

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======= UXS1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UXS1
  * **<color #00a2e8>Official Name</color>**: UDP-glucuronate decarboxylase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=80146|80146]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8NBZ7|Q8NBZ7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UXS1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UXS1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609749|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the NAD-dependent decarboxylation of UDP- glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NAD binding 4|
|RmlD sub bind|
|3Beta HSD|
|UXS1 N|
|Epimerase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|UDP-D-xylose biosynthetic process|
|UDP-glucuronate decarboxylase activity|
|UDP-D-xylose metabolic process|
|NAD+ binding|
|nucleotide-sugar biosynthetic process|
|nucleotide-sugar metabolic process|
|Golgi cisterna membrane|
|protein tetramerization|
|protein complex oligomerization|
|nucleobase-containing small molecule metabolic process|
|carbohydrate derivative biosynthetic process|
|protein homodimerization activity|
|carbohydrate derivative metabolic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|protein-containing complex assembly|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp453|B02 10μM R08 exp453]]|-4.07|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-3.92|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|-3.9|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-3.76|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-3.75|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|-3.68|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-3.42|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|-3.41|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|-3.13|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-3.04|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|-3.03|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-2.96|
|[[:results:exp475|CyclicAMP 200μM R08 exp475]]|-2.93|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|-2.89|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|-2.79|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|-2.74|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|-2.7|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-2.68|
|[[:results:exp359|FK-506 30μM R07 exp359]]|-2.64|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-2.62|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|-2.6|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-2.58|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|-2.54|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-2.54|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|-2.5|
|[[:results:exp423|Zebularine 20μM R07 exp423]]|-2.5|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|-2.46|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-2.36|
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|-2.27|
|[[:results:exp224|CB-839 10μM R05 exp224]]|-2.23|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-2.18|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-2.12|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|-2.11|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|-2.08|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|-2.05|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|-2.02|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|-1.98|
|[[:results:exp504|MK2206 4μM R08 exp504]]|-1.92|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|-1.89|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-1.89|
|[[:results:exp149|SB203580 25μM R03 exp149]]|-1.84|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|-1.83|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|-1.81|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|-1.81|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|-1.78|
|[[:results:exp116|AICAR 240μM R03 exp116]]|-1.75|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|-1.75|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|-1.75|
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|-1.75|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|-1.75|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|-1.74|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|-1.71|
|[[:results:exp211|AICAR 240μM R05 exp211]]|-1.7|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|-1.7|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|2.15|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|2.64|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:med13|MED13]]|0.427|
|[[:human genes:t:tcf4|TCF4]]|0.425|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 75/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|5/28|
|blood|1/28|
|bone|1/26|
|breast|9/33|
|central nervous system|1/56|
|cervix|1/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|4/16|
|kidney|3/21|
|liver|3/20|
|lung|12/75|
|lymphocyte|1/16|
|ovary|2/26|
|pancreas|6/24|
|peripheral nervous system|0/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|3/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12235
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.45 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UXS1 Expression in NALM6 Cells: 7.45'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>