UXT [The Human Chemical-Genetic Interaction Map Project]

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======= UXT =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UXT
  * **<color #00a2e8>Official Name</color>**: ubiquitously expressed prefoldin like chaperone
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8409|8409]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UBK9|Q9UBK9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UXT&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UXT|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300234|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in gene transcription regulation (PubMed:28106301, PubMed:21730289). Acts in concert with the corepressor URI1 to regulate androgen receptor AR-mediated transcription (PubMed:11854421, PubMed:21730289). Together with URI1, associates with chromatin to the NKX3-1 promoter region (PubMed:21730289). Negatively regulates the transcriptional activity of the estrogen receptor ESR1 by inducing its translocation into the cytoplasm (PubMed:28106301). May act as nuclear chaperone that facilitates the formation of the NF-kappa-B enhanceosome and thus positively regulates NF-kappa-B transcription activity (PubMed:17620405, PubMed:21307340). Potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling (PubMed:17554592). Increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association with LRPPRC (PubMed:17554592). Suppresses cell transformation and it might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM (PubMed:17635584). {ECO:0000269|PubMed:11827465, ECO:0000269|PubMed:11854421, ECO:0000269|PubMed:16221885, ECO:0000269|PubMed:17554592, ECO:0000269|PubMed:17620405, ECO:0000269|PubMed:17635584, ECO:0000269|PubMed:21307340, ECO:0000269|PubMed:21730289, ECO:0000269|PubMed:28106301}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Prefoldin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|gamma-tubulin complex|
|establishment of mitochondrion localization, microtubule-mediated|
|mitochondrion transport along microtubule|
|establishment of mitochondrion localization|
|beta-tubulin binding|
|negative regulation of G0 to G1 transition|
|regulation of G0 to G1 transition|
|mitochondrion localization|
|organelle transport along microtubule|
|centrosome cycle|
|transcription coregulator activity|
|microtubule organizing center organization|
|chromatin|
|spindle pole|
|transport along microtubule|
|cytoskeleton-dependent intracellular transport|
|microtubule-based transport|
|actin filament binding|
|microtubule binding|
|transcription corepressor activity|
|microtubule-based movement|
|negative regulation of cell cycle process|
|establishment of organelle localization|
|cytoskeleton|
|chromatin binding|
|microtubule cytoskeleton organization|
|centrosome|
|negative regulation of cell cycle|
|organelle localization|
|microtubule-based process|
|regulation of cell cycle process|
|negative regulation of transcription by RNA polymerase II|
|apoptotic process|
|cell cycle process|
|programmed cell death|
|cell death|
|cytoskeleton organization|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|cell cycle|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|intracellular transport|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|negative regulation of gene expression|
|establishment of localization in cell|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|-2.13|
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|-1.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rnmt|RNMT]]|0.548|
|[[:human genes:a:adsl|ADSL]]|0.539|
|[[:human genes:g:gmppb|GMPPB]]|0.535|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.523|
|[[:human genes:t:telo2|TELO2]]|0.516|
|[[:human genes:t:thg1l|THG1L]]|0.51|
|[[:human genes:a:atxn10|ATXN10]]|0.51|
|[[:human genes:u:uap1|UAP1]]|0.509|
|[[:human genes:v:vrk1|VRK1]]|0.506|
|[[:human genes:m:med4|MED4]]|0.504|
|[[:human genes:r:rtcb|RTCB]]|0.502|
|[[:human genes:d:dpagt1|DPAGT1]]|0.499|
|[[:human genes:a:alg1|ALG1]]|0.499|
|[[:human genes:p:pmm2|PMM2]]|0.495|
|[[:human genes:u:uhrf1|UHRF1]]|0.49|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.486|
|[[:human genes:d:ddx20|DDX20]]|0.485|
|[[:human genes:e:eif4e|EIF4E]]|0.48|
|[[:human genes:r:rpp21|RPP21]]|0.48|
|[[:human genes:g:gpn2|GPN2]]|0.479|
|[[:human genes:y:yars|YARS]]|0.477|
|[[:human genes:n:nars|NARS]]|0.476|
|[[:human genes:o:oraov1|ORAOV1]]|0.473|
|[[:human genes:g:gfpt1|GFPT1]]|0.472|
|[[:human genes:g:gnb1l|GNB1L]]|0.466|
|[[:human genes:r:rptor|RPTOR]]|0.465|
|[[:human genes:e:ercc2|ERCC2]]|0.458|
|[[:human genes:e:eprs|EPRS]]|0.458|
|[[:human genes:s:srp68|SRP68]]|0.457|
|[[:human genes:a:alg13|ALG13]]|0.456|
|[[:human genes:a:alg2|ALG2]]|0.453|
|[[:human genes:t:tti2|TTI2]]|0.452|
|[[:human genes:t:tti1|TTI1]]|0.451|
|[[:human genes:m:med16|MED16]]|0.451|
|[[:human genes:g:gemin8|GEMIN8]]|0.45|
|[[:human genes:g:gemin5|GEMIN5]]|0.449|
|[[:human genes:u:utp23|UTP23]]|0.449|
|[[:human genes:c:csnk2b|CSNK2B]]|0.448|
|[[:human genes:t:triap1|TRIAP1]]|0.447|
|[[:human genes:o:oip5|OIP5]]|0.446|
|[[:human genes:t:ttc4|TTC4]]|0.446|
|[[:human genes:p:ppcs|PPCS]]|0.442|
|[[:human genes:a:aars|AARS]]|0.442|
|[[:human genes:t:tsen54|TSEN54]]|0.441|
|[[:human genes:s:srp14|SRP14]]|0.439|
|[[:human genes:c:ccdc101|CCDC101]]|0.438|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.435|
|[[:human genes:g:gemin7|GEMIN7]]|0.434|
|[[:human genes:r:rpe|RPE]]|0.431|
|[[:human genes:n:nae1|NAE1]]|0.43|
|[[:human genes:t:tbcb|TBCB]]|0.428|
|[[:human genes:p:polr3h|POLR3H]]|0.425|
|[[:human genes:c:cct7|CCT7]]|0.422|
|[[:human genes:t:txnl4b|TXNL4B]]|0.421|
|[[:human genes:s:snapc5|SNAPC5]]|0.42|
|[[:human genes:n:nsmce1|NSMCE1]]|0.419|
|[[:human genes:t:tgs1|TGS1]]|0.419|
|[[:human genes:f:fnta|FNTA]]|0.419|
|[[:human genes:t:ten1|TEN1]]|0.419|
|[[:human genes:d:dr1|DR1]]|0.419|
|[[:human genes:d:dohh|DOHH]]|0.418|
|[[:human genes:t:taf1a|TAF1A]]|0.417|
|[[:human genes:d:dhps|DHPS]]|0.415|
|[[:human genes:a:alg14|ALG14]]|0.412|
|[[:human genes:a:alg5|ALG5]]|0.412|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.411|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.41|
|[[:human genes:r:rpn1|RPN1]]|0.41|
|[[:human genes:w:wdr92|WDR92]]|0.41|
|[[:human genes:t:tbca|TBCA]]|0.409|
|[[:human genes:p:ppp4c|PPP4C]]|0.408|
|[[:human genes:c:chchd4|CHCHD4]]|0.406|
|[[:human genes:e:exoc4|EXOC4]]|0.405|
|[[:human genes:t:tbcd|TBCD]]|0.403|
|[[:human genes:r:rpia|RPIA]]|0.401|
|[[:human genes:d:dad1|DAD1]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 225/683
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|12/28|
|blood|4/26|
|bone|13/25|
|breast|9/30|
|central nervous system|10/49|
|cervix|1/4|
|colorectal|6/17|
|esophagus|7/11|
|fibroblast|0/1|
|gastric|3/14|
|kidney|3/18|
|liver|1/19|
|lung|24/72|
|lymphocyte|5/14|
|ovary|12/25|
|pancreas|7/22|
|peripheral nervous system|2/15|
|plasma cell|4/12|
|prostate|0/1|
|skin|2/20|
|soft tissue|2/7|
|thyroid|2/2|
|upper aerodigestive|17/22|
|urinary tract|15/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1008
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UXT Expression in NALM6 Cells: 5.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>