VAMP8 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= VAMP8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: VAMP8
  * **<color #00a2e8>Official Name</color>**: vesicle associated membrane protein 8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8673|8673]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BV40|Q9BV40]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=VAMP8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20VAMP8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603177|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an integral membrane protein that belongs to the synaptobrevin/vesicle-associated membrane protein subfamily of soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs). The encoded protein is involved in the fusion of synaptic vesicles with the presynaptic membrane.[provided by RefSeq, Jun 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  SNAREs, soluble N-ethylmaleimide-sensitive factor- attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t-SNARE complex (PubMed:23217709, PubMed:25686604). Also required for dense-granule secretion in platelets (PubMed:12130530). Plays also a role in regulated enzyme secretion in pancreatic acinar cells (By similarity). Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells (By similarity). Involved in the homotypic fusion of early and late endosomes (By similarity). {ECO:0000250|UniProtKB:Q9WUF4, ECO:0000269|PubMed:12130530, ECO:0000269|PubMed:23217709, ECO:0000269|PubMed:25686604}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Synaptobrevin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mucin granule|
|eosinophil mediated immunity|
|autophagosome membrane docking|
|eosinophil activation involved in immune response|
|mucus secretion|
|eosinophil activation|
|eosinophil degranulation|
|positive regulation of histamine secretion by mast cell|
|regulation of histamine secretion by mast cell|
|chloride channel inhibitor activity|
|positive regulation of mast cell activation involved in immune response|
|positive regulation of mast cell degranulation|
|positive regulation of mast cell activation|
|secretion by tissue|
|positive regulation of leukocyte degranulation|
|positive regulation of myeloid leukocyte mediated immunity|
|autophagosome maturation|
|regulation of mast cell degranulation|
|regulation of mast cell activation involved in immune response|
|positive regulation of neurotransmitter transport|
|regulation of mast cell activation|
|SNARE complex|
|regulation of leukocyte degranulation|
|positive regulation of regulated secretory pathway|
|clathrin-coated vesicle membrane|
|regulation of myeloid leukocyte mediated immunity|
|azurophil granule membrane|
|carbohydrate derivative transport|
|body fluid secretion|
|phagocytic vesicle membrane|
|tertiary granule membrane|
|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|
|antigen processing and presentation of exogenous peptide antigen via MHC class I|
|recycling endosome membrane|
|positive regulation of exocytosis|
|specific granule membrane|
|regulation of protein localization to plasma membrane|
|viral entry into host cell|
|antigen processing and presentation of peptide antigen via MHC class I|
|secretory granule membrane|
|post-Golgi vesicle-mediated transport|
|entry into host cell|
|entry into host|
|regulation of protein localization to cell periphery|
|recycling endosome|
|late endosome membrane|
|positive regulation of hormone secretion|
|positive regulation of leukocyte mediated immunity|
|positive regulation of inflammatory response|
|vesicle|
|regulation of neurotransmitter transport|
|early endosome membrane|
|interaction with host|
|macroautophagy|
|regulation of regulated secretory pathway|
|organelle localization by membrane tethering|
|antigen processing and presentation of exogenous peptide antigen|
|membrane docking|
|antigen processing and presentation of exogenous antigen|
|regulation of protein localization to membrane|
|antigen processing and presentation of peptide antigen|
|viral life cycle|
|negative regulation of secretion by cell|
|regulation of leukocyte mediated immunity|
|positive regulation of intracellular transport|
|antigen processing and presentation|
|positive regulation of immune effector process|
|regulation of exocytosis|
|negative regulation of secretion|
|protein-containing complex disassembly|
|early endosome|
|autophagy|
|process utilizing autophagic mechanism|
|regulation of hormone secretion|
|positive regulation of ion transport|
|lysosomal membrane|
|regulation of inflammatory response|
|regulation of intracellular transport|
|Golgi vesicle transport|
|cellular component disassembly|
|positive regulation of secretion by cell|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|positive regulation of secretion|
|regulation of immune effector process|
|positive regulation of defense response|
|negative regulation of transport|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|regulation of body fluid levels|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|regulation of hormone levels|
|regulation of cellular protein localization|
|regulation of vesicle-mediated transport|
|organelle localization|
|myeloid leukocyte activation|
|positive regulation of response to external stimulus|
|regulation of leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulation of cell activation|
|perinuclear region of cytoplasm|
|regulation of ion transport|
|viral process|
|regulated exocytosis|
|regulation of secretion by cell|
|regulation of defense response|
|leukocyte mediated immunity|
|symbiotic process|
|exocytosis|
|regulation of secretion|
|interspecies interaction between organisms|
|membrane organization|
|positive regulation of immune response|
|regulation of cellular localization|
|leukocyte activation|
|positive regulation of transport|
|secretion by cell|
|regulation of protein localization|
|export from cell|
|cell activation|
|immune effector process|
|regulation of response to external stimulus|
|secretion|
|regulation of immune response|
|positive regulation of immune system process|
|regulation of response to stress|
|protein transport|
|peptide transport|
|amide transport|
|establishment of protein localization|
|regulation of immune system process|
|positive regulation of multicellular organismal process|
|cellular catabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|regulation of transport|
|immune response|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|1.97|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12353
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.13 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='VAMP8 Expression in NALM6 Cells: -3.13'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>