VCAM1 [The Human Chemical-Genetic Interaction Map Project]

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======= VCAM1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: VCAM1
  * **<color #00a2e8>Official Name</color>**: vascular cell adhesion molecule 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7412|7412]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P19320|P19320]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=VCAM1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20VCAM1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/192225|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|C2-set|
|ig|
|I-set|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cardiac neuron differentiation|
|alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex|
|cell-cell adhesion in response to extracellular stimulus|
|membrane to membrane docking|
|primary amine oxidase activity|
|chronic inflammatory response|
|leukocyte tethering or rolling|
|leukocyte adhesion to vascular endothelial cell|
|calcium-mediated signaling using intracellular calcium source|
|innervation|
|podosome|
|heterotypic cell-cell adhesion|
|cellular response to amyloid-beta|
|cellular extravasation|
|cellular response to vascular endothelial growth factor stimulus|
|autonomic nervous system development|
|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|
|response to amyloid-beta|
|response to nicotine|
|leukocyte cell-cell adhesion|
|response to zinc ion|
|cell adhesion molecule binding|
|microvillus|
|amine metabolic process|
|acute inflammatory response|
|apical part of cell|
|interferon-gamma-mediated signaling pathway|
|filopodium|
|nerve development|
|positive regulation of T cell proliferation|
|sarcolemma|
|B cell differentiation|
|cardiocyte differentiation|
|response to ethanol|
|cell-matrix adhesion|
|positive regulation of lymphocyte proliferation|
|positive regulation of mononuclear cell proliferation|
|integrin binding|
|positive regulation of leukocyte proliferation|
|calcium-mediated signaling|
|response to ionizing radiation|
|B cell activation|
|regulation of T cell proliferation|
|cellular response to interferon-gamma|
|membrane docking|
|response to interferon-gamma|
|cell-substrate adhesion|
|positive regulation of T cell activation|
|regulation of lymphocyte proliferation|
|cell chemotaxis|
|regulation of mononuclear cell proliferation|
|response to nutrient|
|positive regulation of leukocyte cell-cell adhesion|
|regulation of leukocyte proliferation|
|response to alcohol|
|lymphocyte differentiation|
|cellular response to tumor necrosis factor|
|positive regulation of cell-cell adhesion|
|early endosome|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|response to tumor necrosis factor|
|cellular response to extracellular stimulus|
|aging|
|regulation of leukocyte cell-cell adhesion|
|response to antibiotic|
|response to lipopolysaccharide|
|regulation of T cell activation|
|cellular response to peptide|
|response to molecule of bacterial origin|
|leukocyte differentiation|
|cellular response to external stimulus|
|second-messenger-mediated signaling|
|extracellular matrix organization|
|response to hypoxia|
|response to decreased oxygen levels|
|positive regulation of lymphocyte activation|
|response to metal ion|
|leukocyte migration|
|response to oxygen levels|
|lymphocyte activation|
|extracellular structure organization|
|external side of plasma membrane|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|response to radiation|
|response to peptide|
|response to nutrient levels|
|inflammatory response|
|cellular response to growth factor stimulus|
|cell-cell adhesion|
|response to toxic substance|
|regulation of lymphocyte activation|
|heart development|
|response to growth factor|
|response to extracellular stimulus|
|response to inorganic substance|
|chemotaxis|
|taxis|
|hemopoiesis|
|cellular response to organonitrogen compound|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|cell surface|
|regulation of cell activation|
|immune system development|
|cellular response to nitrogen compound|
|cytokine-mediated signaling pathway|
|regulation of cell adhesion|
|response to bacterium|
|innate immune response|
|response to lipid|
|circulatory system development|
|positive regulation of cell population proliferation|
|leukocyte activation|
|cell adhesion|
|biological adhesion|
|defense response to other organism|
|oxidation-reduction process|
|cell migration|
|Golgi apparatus|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|endoplasmic reticulum|
|neuron differentiation|
|response to drug|
|cellular response to oxygen-containing compound|
|cell activation|
|localization of cell|
|cell motility|
|response to nitrogen compound|
|response to cytokine|
|regulation of immune response|
|positive regulation of immune system process|
|response to abiotic stimulus|
|cellular response to endogenous stimulus|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|defense response|
|integral component of plasma membrane|
|response to endogenous stimulus|
|generation of neurons|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|extracellular space|
|regulation of cell population proliferation|
|neurogenesis|
|regulation of immune system process|
|intracellular signal transduction|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp145|PNU96415E 10μM R03 exp145]]|1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6225
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='VCAM1 Expression in NALM6 Cells: -3.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>