VDAC2 [The Human Chemical-Genetic Interaction Map Project]

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======= VDAC2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: VDAC2
  * **<color #00a2e8>Official Name</color>**: voltage dependent anion channel 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7417|7417]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P45880|P45880]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=VDAC2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20VDAC2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/193245|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation- selective.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Porin 3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|porin activity|
|voltage-gated anion channel activity|
|pore complex|
|binding of sperm to zona pellucida|
|mitochondrial nucleoid|
|sperm-egg recognition|
|nucleotide binding|
|negative regulation of protein polymerization|
|cell-cell recognition|
|acrosomal vesicle|
|negative regulation of intrinsic apoptotic signaling pathway|
|synaptic vesicle|
|negative regulation of protein complex assembly|
|single fertilization|
|inorganic anion transport|
|regulation of intrinsic apoptotic signaling pathway|
|mitochondrial outer membrane|
|fertilization|
|regulation of protein polymerization|
|negative regulation of apoptotic signaling pathway|
|cell recognition|
|anion transmembrane transport|
|regulation of apoptotic signaling pathway|
|regulation of protein complex assembly|
|negative regulation of intracellular signal transduction|
|anion transport|
|negative regulation of cellular component organization|
|sexual reproduction|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|ion transmembrane transport|
|regulation of cellular component biogenesis|
|multi-organism reproductive process|
|negative regulation of cell death|
|mitochondrion|
|negative regulation of signal transduction|
|transmembrane transport|
|negative regulation of cell communication|
|negative regulation of signaling|
|ion transport|
|reproductive process|
|reproduction|
|regulation of apoptotic process|
|regulation of programmed cell death|
|negative regulation of response to stimulus|
|regulation of cell death|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|1.73|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|1.81|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|1.82|
|[[:results:exp210|LB-100 2μM R05 exp210]]|1.91|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|1.93|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|1.94|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|2.02|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|2.08|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|2.08|
|[[:results:exp415|Trichostatin-A 0.06μM R07 exp415]]|2.08|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2.15|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|2.16|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|2.22|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|2.27|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|2.28|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|2.38|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|2.56|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|2.56|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|2.59|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|2.6|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|2.63|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|2.66|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|2.67|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|2.69|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|2.71|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|2.75|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|2.77|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|2.83|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.85|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|2.93|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|2.98|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|3|
|[[:results:exp211|AICAR 240μM R05 exp211]]|3.04|
|[[:results:exp134|MS023 2μM R03 exp134]]|3.06|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|3.09|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|3.13|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|3.32|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|3.37|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|3.48|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|3.61|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|3.76|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|3.76|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|3.82|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|3.83|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|3.84|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|3.94|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|4.39|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|4.83|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|4.84|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|4.91|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|5.29|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|5.29|
|[[:results:exp116|AICAR 240μM R03 exp116]]|5.37|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|6.41|
|[[:results:exp135|MS023 7μM R03 exp135]]|6.51|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:b:bak1|BAK1]]|0.822|
|[[:human genes:m:march5|MARCH5]]|0.802|
|[[:human genes:a:apaf1|APAF1]]|0.756|
|[[:human genes:u:ubqln1|UBQLN1]]|0.741|
|[[:human genes:c:casp9|CASP9]]|0.722|
|[[:human genes:p:plaa|PLAA]]|0.674|
|[[:human genes:s:serf2|SERF2]]|0.672|
|[[:human genes:c:cycs|CYCS]]|0.667|
|[[:human genes:f:faf2|FAF2]]|0.65|
|[[:human genes:d:diablo|DIABLO]]|0.627|
|[[:human genes:h:hccs|HCCS]]|0.606|
|[[:human genes:d:dohh|DOHH]]|0.597|
|[[:human genes:a:atad1|ATAD1]]|0.57|
|[[:human genes:m:mfn1|MFN1]]|0.567|
|[[:human genes:r:romo1|ROMO1]]|0.547|
|[[:human genes:m:mlst8|MLST8]]|0.535|
|[[:human genes:s:stau1|STAU1]]|0.507|
|[[:human genes:t:triap1|TRIAP1]]|0.497|
|[[:human genes:g:gabpa|GABPA]]|0.494|
|[[:human genes:b:bcl2l11|BCL2L11]]|0.488|
|[[:human genes:t:thg1l|THG1L]]|0.487|
|[[:human genes:e:eny2|ENY2]]|0.483|
|[[:human genes:r:rptor|RPTOR]]|0.482|
|[[:human genes:m:metap2|METAP2]]|0.48|
|[[:human genes:h:hspd1|HSPD1]]|0.48|
|[[:human genes:m:mtor|MTOR]]|0.479|
|[[:human genes:b:bap1|BAP1]]|0.477|
|[[:human genes:b:bptf|BPTF]]|0.477|
|[[:human genes:z:zzz3|ZZZ3]]|0.475|
|[[:human genes:u:uap1|UAP1]]|0.469|
|[[:human genes:c:crls1|CRLS1]]|0.468|
|[[:human genes:p:pdpk1|PDPK1]]|0.463|
|[[:human genes:w:wdr24|WDR24]]|0.46|
|[[:human genes:r:rad23b|RAD23B]]|0.455|
|[[:human genes:f:fbxo11|FBXO11]]|0.446|
|[[:human genes:s:slmo2|SLMO2]]|0.446|
|[[:human genes:g:gfpt1|GFPT1]]|0.446|
|[[:human genes:d:ddhd2|DDHD2]]|0.442|
|[[:human genes:m:mapkap1|MAPKAP1]]|0.442|
|[[:human genes:k:kdsr|KDSR]]|0.44|
|[[:human genes:e:elf2|ELF2]]|0.44|
|[[:human genes:n:nsd1|NSD1]]|0.438|
|[[:human genes:g:gnas|GNAS]]|0.437|
|[[:human genes:k:kctd5|KCTD5]]|0.437|
|[[:human genes:l:lamtor4|LAMTOR4]]|0.435|
|[[:human genes:f:fech|FECH]]|0.433|
|[[:human genes:h:hars|HARS]]|0.433|
|[[:human genes:m:meaf6|MEAF6]]|0.43|
|[[:human genes:c:cept1|CEPT1]]|0.43|
|[[:human genes:t:tp53|TP53]]|0.43|
|[[:human genes:g:gmppb|GMPPB]]|0.423|
|[[:human genes:m:mios|MIOS]]|0.422|
|[[:human genes:m:mcl1|MCL1]]|0.421|
|[[:human genes:v:vhl|VHL]]|0.421|
|[[:human genes:n:nudc|NUDC]]|0.42|
|[[:human genes:u:ube2g2|UBE2G2]]|0.419|
|[[:human genes:s:srp14|SRP14]]|0.418|
|[[:human genes:s:sec16a|SEC16A]]|0.417|
|[[:human genes:s:slc4a7|SLC4A7]]|0.417|
|[[:human genes:o:opa1|OPA1]]|0.414|
|[[:human genes:w:wdr59|WDR59]]|0.406|
|[[:human genes:t:trim28|TRIM28]]|0.405|
|[[:human genes:g:gtf3a|GTF3A]]|0.403|
|[[:human genes:r:rpn1|RPN1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3799
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.82 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='VDAC2 Expression in NALM6 Cells: 6.82'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>