VEGFC [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= VEGFC =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: VEGFC
  * **<color #00a2e8>Official Name</color>**: vascular endothelial growth factor C
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7424|7424]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P49767|P49767]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=VEGFC&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20VEGFC|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601528|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family. The encoded protein promotes angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. The proprotein is further cleaved into a fully processed form that can bind and activate VEGFR-2 and VEGFR-3 receptors. [provided by RefSeq, Apr 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates KDR/VEGFR2 and FLT4/VEGFR3 receptors. {ECO:0000269|PubMed:20145116}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PDGF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of lymphangiogenesis|
|vascular endothelial growth factor receptor 3 binding|
|regulation of lymphangiogenesis|
|positive regulation of mast cell chemotaxis|
|vascular endothelial growth factor receptor binding|
|regulation of mast cell chemotaxis|
|induction of positive chemotaxis|
|vascular endothelial growth factor signaling pathway|
|positive regulation of neuroblast proliferation|
|positive regulation of positive chemotaxis|
|regulation of positive chemotaxis|
|positive regulation of protein autophosphorylation|
|substrate-dependent cell migration|
|regulation of vascular endothelial growth factor receptor signaling pathway|
|regulation of neuroblast proliferation|
|chemoattractant activity|
|positive regulation of stem cell proliferation|
|cellular response to vascular endothelial growth factor stimulus|
|negative regulation of blood pressure|
|regulation of protein autophosphorylation|
|positive chemotaxis|
|positive regulation of neural precursor cell proliferation|
|positive regulation of blood vessel endothelial cell migration|
|sprouting angiogenesis|
|regulation of stem cell proliferation|
|vascular endothelial growth factor receptor signaling pathway|
|platelet alpha granule lumen|
|positive regulation of cell division|
|regulation of neural precursor cell proliferation|
|positive regulation of leukocyte chemotaxis|
|regulation of blood vessel endothelial cell migration|
|positive regulation of endothelial cell proliferation|
|cellular response to leukemia inhibitory factor|
|response to leukemia inhibitory factor|
|positive regulation of endothelial cell migration|
|regulation of leukocyte chemotaxis|
|platelet degranulation|
|positive regulation of leukocyte migration|
|regulation of endothelial cell proliferation|
|positive regulation of chemotaxis|
|positive regulation of epithelial cell migration|
|morphogenesis of embryonic epithelium|
|regulation of endothelial cell migration|
|growth factor activity|
|positive regulation of angiogenesis|
|regulation of cell division|
|regulation of blood pressure|
|positive regulation of vasculature development|
|positive regulation of epithelial cell proliferation|
|regulation of leukocyte migration|
|regulation of chemotaxis|
|regulation of epithelial cell migration|
|positive regulation of protein secretion|
|regulation of cellular response to growth factor stimulus|
|regulation of angiogenesis|
|positive regulation of peptide secretion|
|angiogenesis|
|regulation of vasculature development|
|regulation of epithelial cell proliferation|
|response to hypoxia|
|response to decreased oxygen levels|
|response to oxygen levels|
|blood circulation|
|circulatory system process|
|positive regulation of secretion by cell|
|blood vessel morphogenesis|
|positive regulation of protein transport|
|morphogenesis of an epithelium|
|positive regulation of secretion|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|positive regulation of neurogenesis|
|blood vessel development|
|regulation of peptide secretion|
|positive regulation of cell migration|
|cellular response to growth factor stimulus|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|vasculature development|
|cardiovascular system development|
|positive regulation of cell motility|
|response to growth factor|
|positive regulation of nervous system development|
|positive regulation of cellular component movement|
|positive regulation of cell development|
|chemotaxis|
|taxis|
|positive regulation of locomotion|
|tissue morphogenesis|
|embryonic morphogenesis|
|positive regulation of response to external stimulus|
|tube morphogenesis|
|regulated exocytosis|
|regulation of protein transport|
|enzyme linked receptor protein signaling pathway|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|exocytosis|
|regulation of secretion|
|regulation of neurogenesis|
|tube development|
|regulation of cell migration|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|regulation of nervous system development|
|regulation of cell development|
|animal organ morphogenesis|
|cell migration|
|positive regulation of cell differentiation|
|embryo development|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|secretion by cell|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|response to drug|
|regulation of protein localization|
|export from cell|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|cell motility|
|localization of cell|
|regulation of response to external stimulus|
|response to cytokine|
|epithelium development|
|secretion|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|response to abiotic stimulus|
|positive regulation of protein modification process|
|locomotion|
|positive regulation of developmental process|
|regulation of protein phosphorylation|
|generation of neurons|
|movement of cell or subcellular component|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|neurogenesis|
|regulation of immune system process|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of protein modification process|
|regulation of transport|
|extracellular region|
|vesicle-mediated transport|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10831
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='VEGFC Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>