VIL1 [The Human Chemical-Genetic Interaction Map Project]

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======= VIL1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: VIL1
  * **<color #00a2e8>Official Name</color>**: villin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7429|7429]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P09327|P09327]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=VIL1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20VIL1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/193040|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Epithelial cell-specific Ca(2+)-regulated actin- modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the intestinal epithelial cell morphology, cell invasion, cell migration and apoptosis. Protects against apoptosis induced by dextran sodium sulfate (DSS) in the gastrointestinal epithelium. Appears to regulate cell death by maintaining mitochondrial integrity. Enhances hepatocyte growth factor (HGF)-induced epithelial cell motility, chemotaxis and wound repair. Upon S.flexneri cell infection, its actin-severing activity enhances actin-based motility of the bacteria and plays a role during the dissemination. {ECO:0000269|PubMed:11500485, ECO:0000269|PubMed:14594952, ECO:0000269|PubMed:15084600, ECO:0000269|PubMed:15272027, ECO:0000269|PubMed:15342783, ECO:0000269|PubMed:16921170, ECO:0000269|PubMed:17182858, ECO:0000269|PubMed:17229814, ECO:0000269|PubMed:17606613, ECO:0000269|PubMed:18054784, ECO:0000269|PubMed:18198174, ECO:0000269|PubMed:19808673, ECO:0000269|PubMed:3087992}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|VHP|
|Gelsolin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cytoplasmic actin-based contraction involved in cell motility|
|intestinal D-glucose absorption|
|terminal web assembly|
|lysophosphatidic acid binding|
|intestinal hexose absorption|
|positive regulation of lamellipodium morphogenesis|
|regulation of microvillus length|
|actin filament bundle|
|actin filament severing|
|actin filament depolymerization|
|regulation of lamellipodium morphogenesis|
|regulation of microvillus organization|
|regulation of cell projection size|
|positive regulation of actin filament depolymerization|
|barbed-end actin filament capping|
|cellular response to hepatocyte growth factor stimulus|
|filopodium tip|
|response to hepatocyte growth factor|
|positive regulation of protein depolymerization|
|cysteine-type endopeptidase inhibitor activity involved in apoptotic process|
|regulation of actin nucleation|
|positive regulation of lamellipodium organization|
|actin filament polymerization|
|positive regulation of multicellular organism growth|
|intestinal absorption|
|actin nucleation|
|actin filament capping|
|protein depolymerization|
|negative regulation of actin filament depolymerization|
|positive regulation of protein complex disassembly|
|regulation of lamellipodium organization|
|cortical actin cytoskeleton organization|
|cellular response to epidermal growth factor stimulus|
|response to epidermal growth factor|
|cortical cytoskeleton organization|
|epidermal growth factor receptor signaling pathway|
|actin polymerization or depolymerization|
|regulation of actin filament depolymerization|
|brush border|
|negative regulation of actin filament polymerization|
|positive regulation of protein localization to plasma membrane|
|negative regulation of protein depolymerization|
|positive regulation of actin filament bundle assembly|
|positive regulation of protein localization to cell periphery|
|microvillus|
|regulation of multicellular organism growth|
|negative regulation of protein polymerization|
|negative regulation of protein complex disassembly|
|ERBB signaling pathway|
|filopodium|
|digestive system process|
|carbohydrate transport|
|phosphatidylinositol-4,5-bisphosphate binding|
|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|regulation of protein depolymerization|
|protein polymerization|
|actin-mediated cell contraction|
|negative regulation of cysteine-type endopeptidase activity|
|positive regulation of actin filament polymerization|
|ruffle|
|regulation of actin filament bundle assembly|
|regulation of protein localization to plasma membrane|
|actin filament-based movement|
|digestion|
|regulation of protein complex disassembly|
|regulation of protein localization to cell periphery|
|positive regulation of protein localization to membrane|
|positive regulation of protein polymerization|
|negative regulation of protein complex assembly|
|negative regulation of supramolecular fiber organization|
|regulation of wound healing|
|cellular protein complex disassembly|
|negative regulation of cytoskeleton organization|
|positive regulation of epithelial cell migration|
|regulation of cell shape|
|regulation of actin filament polymerization|
|regulation of response to wounding|
|positive regulation of developmental growth|
|lamellipodium|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|regulation of protein localization to membrane|
|positive regulation of supramolecular fiber organization|
|actin filament binding|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|positive regulation of cytoskeleton organization|
|regulation of epithelial cell migration|
|regulation of protein polymerization|
|actin filament organization|
|protein-containing complex disassembly|
|regulation of cysteine-type endopeptidase activity|
|negative regulation of endopeptidase activity|
|positive regulation of protein complex assembly|
|negative regulation of peptidase activity|
|positive regulation of growth|
|regulation of actin filament organization|
|positive regulation of cellular protein localization|
|regulation of developmental growth|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|negative regulation of proteolysis|
|negative regulation of organelle organization|
|regulation of cellular component size|
|positive regulation of cell projection organization|
|regulation of actin filament-based process|
|cellular component disassembly|
|regulation of endopeptidase activity|
|regulation of peptidase activity|
|regulation of protein complex assembly|
|negative regulation of hydrolase activity|
|supramolecular fiber organization|
|regulation of cell morphogenesis|
|actin cytoskeleton organization|
|cellular response to growth factor stimulus|
|positive regulation of cell migration|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of anatomical structure size|
|positive regulation of cellular component biogenesis|
|positive regulation of cell motility|
|response to growth factor|
|positive regulation of cellular component movement|
|regulation of cellular protein localization|
|regulation of cytoskeleton organization|
|positive regulation of locomotion|
|actin filament-based process|
|positive regulation of organelle organization|
|regulation of growth|
|epithelial cell differentiation|
|response to bacterium|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|enzyme linked receptor protein signaling pathway|
|calcium ion binding|
|regulation of proteolysis|
|organelle assembly|
|negative regulation of catalytic activity|
|cellular protein-containing complex assembly|
|regulation of cell migration|
|protein homodimerization activity|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|regulation of cell motility|
|regulation of cellular localization|
|apoptotic process|
|regulation of cellular component biogenesis|
|regulation of locomotion|
|negative regulation of cell death|
|regulation of cellular component movement|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|programmed cell death|
|regulation of anatomical structure morphogenesis|
|identical protein binding|
|localization of cell|
|cell motility|
|cell death|
|negative regulation of protein metabolic process|
|cytoskeleton organization|
|epithelium development|
|negative regulation of molecular function|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|regulation of hydrolase activity|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|positive regulation of developmental process|
|response to endogenous stimulus|
|regulation of response to stress|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|protein-containing complex assembly|
|regulation of programmed cell death|
|regulation of cell death|
|positive regulation of multicellular organismal process|
|tissue development|
|protein-containing complex subunit organization|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|-1.97|
|[[:results:exp293|Myriocin 25μM R06 exp293]]|1.9|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11293
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.15 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='VIL1 Expression in NALM6 Cells: 4.15'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>