VIP [The Human Chemical-Genetic Interaction Map Project]

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======= VIP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: VIP
  * **<color #00a2e8>Official Name</color>**: vasoactive intestinal peptide
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7432|7432]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P01282|P01282]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=VIP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20VIP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/192320|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder. {ECO:0000269|PubMed:15013843}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Hormone 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|epinephrine secretion|
|epinephrine transport|
|positive regulation of epinephrine secretion|
|catecholamine secretion|
|prolactin secretion|
|positive regulation of penile erection|
|regulation of penile erection|
|regulation of epinephrine secretion|
|peptide hormone receptor binding|
|positive regulation of catecholamine secretion|
|catecholamine transport|
|monoamine transport|
|neuropeptide hormone activity|
|negative regulation of potassium ion transport|
|positive regulation of amine transport|
|regulation of sensory perception of pain|
|regulation of sensory perception|
|mRNA stabilization|
|negative regulation of smooth muscle cell proliferation|
|RNA stabilization|
|negative regulation of mRNA catabolic process|
|positive regulation of blood vessel diameter|
|peptide hormone secretion|
|negative regulation of RNA catabolic process|
|regulation of catecholamine secretion|
|hormone secretion|
|body fluid secretion|
|positive regulation of reproductive process|
|negative regulation of mRNA metabolic process|
|hormone transport|
|regulation of amine transport|
|positive regulation of endothelial cell proliferation|
|regulation of potassium ion transport|
|phospholipase C-activating G protein-coupled receptor signaling pathway|
|hormone activity|
|adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|regulation of endothelial cell proliferation|
|regulation of smooth muscle cell proliferation|
|perikaryon|
|regulation of nervous system process|
|organic hydroxy compound transport|
|regulation of blood vessel diameter|
|regulation of tube diameter|
|regulation of tube size|
|cAMP-mediated signaling|
|negative regulation of ion transport|
|protein secretion|
|establishment of protein localization to extracellular region|
|regulation of reproductive process|
|protein localization to extracellular region|
|signal release|
|vascular process in circulatory system|
|cyclic-nucleotide-mediated signaling|
|peptide secretion|
|regulation of mRNA stability|
|regulation of RNA stability|
|positive regulation of epithelial cell proliferation|
|regulation of mRNA catabolic process|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|positive regulation of protein catabolic process|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|negative regulation of cellular catabolic process|
|learning or memory|
|cognition|
|negative regulation of catabolic process|
|neuron projection|
|regulation of mRNA metabolic process|
|regulation of epithelial cell proliferation|
|second-messenger-mediated signaling|
|regulation of protein catabolic process|
|regulation of metal ion transport|
|blood circulation|
|circulatory system process|
|positive regulation of secretion by cell|
|positive regulation of catabolic process|
|positive regulation of secretion|
|negative regulation of transport|
|regulation of body fluid levels|
|positive regulation of multi-organism process|
|regulation of anatomical structure size|
|posttranscriptional regulation of gene expression|
|regulation of hormone levels|
|behavior|
|regulation of system process|
|negative regulation of cell population proliferation|
|regulation of ion transport|
|regulation of secretion by cell|
|regulation of multi-organism process|
|regulation of secretion|
|regulation of cellular catabolic process|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|positive regulation of cell population proliferation|
|positive regulation of transport|
|negative regulation of cell death|
|regulation of catabolic process|
|secretion by cell|
|regulation of protein localization|
|export from cell|
|cell-cell signaling|
|secretion|
|G protein-coupled receptor signaling pathway|
|negative regulation of RNA metabolic process|
|nervous system process|
|negative regulation of nucleobase-containing compound metabolic process|
|protein transport|
|peptide transport|
|regulation of apoptotic process|
|regulation of programmed cell death|
|amide transport|
|establishment of protein localization|
|regulation of cell population proliferation|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|nitrogen compound transport|
|regulation of transport|
|extracellular region|
|system process|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp182|IU1-47 25μM R04 exp182]]|1.71|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|1.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18918
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='VIP Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>