VIT [The Human Chemical-Genetic Interaction Map Project]

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======= VIT =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: VIT
  * **<color #00a2e8>Official Name</color>**: vitrin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5212|5212]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6UXI7|Q6UXI7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=VIT&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20VIT|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617693|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an extracellular matrix (ECM) protein. The protein may be associated with cell adhesion and migration. High levels of expression of the protein in specific parts of the brain suggest its likely role in neural development. [provided by RefSeq, Jun 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|LCCL|
|VWA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|interstitial matrix|
|chondrocyte morphogenesis involved in endochondral bone morphogenesis|
|chondrocyte morphogenesis|
|growth plate cartilage chondrocyte morphogenesis|
|growth plate cartilage morphogenesis|
|glycosaminoglycan binding|
|chondrocyte development involved in endochondral bone morphogenesis|
|growth plate cartilage chondrocyte differentiation|
|cartilage morphogenesis|
|chondrocyte differentiation involved in endochondral bone morphogenesis|
|growth plate cartilage development|
|endochondral bone growth|
|chondrocyte development|
|bone growth|
|cartilage development involved in endochondral bone morphogenesis|
|endochondral bone morphogenesis|
|chondrocyte differentiation|
|organ growth|
|spinal cord development|
|bone morphogenesis|
|positive regulation of cell-substrate adhesion|
|cartilage development|
|bone development|
|regulation of cell-substrate adhesion|
|connective tissue development|
|extracellular matrix|
|skeletal system morphogenesis|
|extracellular matrix organization|
|collagen-containing extracellular matrix|
|extracellular structure organization|
|developmental growth|
|growth|
|positive regulation of cell adhesion|
|skeletal system development|
|cell morphogenesis involved in differentiation|
|tissue morphogenesis|
|regulation of cell adhesion|
|cell morphogenesis|
|cellular component morphogenesis|
|animal organ morphogenesis|
|central nervous system development|
|extracellular space|
|cell development|
|tissue development|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16527
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='VIT Expression in NALM6 Cells: -4.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>