VLDLR [The Human Chemical-Genetic Interaction Map Project]

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======= VLDLR =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: VLDLR
  * **<color #00a2e8>Official Name</color>**: very low density lipoprotein receptor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7436|7436]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P98155|P98155]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=VLDLR&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20VLDLR|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/192977|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. This gene encodes a lipoprotein receptor that is a member of the LDLR family and plays important roles in VLDL-triglyceride metabolism and the reelin signaling pathway. Mutations in this gene cause VLDLR-associated cerebellar hypoplasia. Alternative splicing generates multiple transcript variants encoding distinct isoforms for this gene. [provided by RefSeq, Aug 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ldl recept a|
|Ldl recept b|
|EGF CA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|reelin receptor activity|
|very-low-density lipoprotein particle binding|
|very-low-density lipoprotein particle receptor activity|
|glycoprotein transport|
|very-low-density lipoprotein particle clearance|
|reelin-mediated signaling pathway|
|low-density lipoprotein particle receptor catabolic process|
|low-density lipoprotein receptor particle metabolic process|
|low-density lipoprotein particle receptor activity|
|cargo receptor activity|
|apolipoprotein binding|
|very-low-density lipoprotein particle|
|receptor catabolic process|
|plasma lipoprotein particle clearance|
|ventral spinal cord development|
|clathrin-coated pit|
|dendrite morphogenesis|
|calcium-dependent protein binding|
|carbohydrate derivative transport|
|regulation of plasma lipoprotein particle levels|
|positive regulation of dendrite development|
|dendrite development|
|receptor metabolic process|
|spinal cord development|
|cholesterol metabolic process|
|memory|
|secondary alcohol metabolic process|
|sterol metabolic process|
|regulation of dendrite development|
|receptor complex|
|receptor-mediated endocytosis|
|learning or memory|
|axon guidance|
|steroid metabolic process|
|neuron projection guidance|
|positive regulation of neuron projection development|
|lipid transport|
|cognition|
|lysosomal membrane|
|alcohol metabolic process|
|lipid localization|
|positive regulation of neuron differentiation|
|axonogenesis|
|positive regulation of cell projection organization|
|axon development|
|cell morphogenesis involved in neuron differentiation|
|organic hydroxy compound metabolic process|
|positive regulation of neurogenesis|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|regulation of neuron projection development|
|cell part morphogenesis|
|positive regulation of protein kinase activity|
|positive regulation of nervous system development|
|positive regulation of cell development|
|chemotaxis|
|taxis|
|endocytosis|
|cell morphogenesis involved in differentiation|
|behavior|
|positive regulation of kinase activity|
|cellular protein catabolic process|
|regulation of neuron differentiation|
|positive regulation of transferase activity|
|neuron projection development|
|import into cell|
|protein catabolic process|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|calcium ion binding|
|cell morphogenesis|
|regulation of protein kinase activity|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|regulation of kinase activity|
|cellular macromolecule catabolic process|
|regulation of nervous system development|
|regulation of cell development|
|positive regulation of cell differentiation|
|regulation of transferase activity|
|central nervous system development|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|macromolecule catabolic process|
|positive regulation of phosphorylation|
|organonitrogen compound catabolic process|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|cell projection organization|
|positive regulation of cellular component organization|
|lipid metabolic process|
|positive regulation of protein modification process|
|locomotion|
|positive regulation of developmental process|
|nervous system process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|protein transport|
|generation of neurons|
|peptide transport|
|movement of cell or subcellular component|
|amide transport|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|neurogenesis|
|cell development|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|organic substance catabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|regulation of protein modification process|
|nitrogen compound transport|
|vesicle-mediated transport|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|-1.82|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|1.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13835
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.95 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='VLDLR Expression in NALM6 Cells: 8.95'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>