VMA21 [The Human Chemical-Genetic Interaction Map Project]

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======= VMA21 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: VMA21
  * **<color #00a2e8>Official Name</color>**: vacuolar ATPase assembly factor VMA21
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=203547|203547]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q3ZAQ7|Q3ZAQ7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=VMA21&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20VMA21|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300913|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a chaperone for assembly of lysosomal vacuolar ATPase.[provided by RefSeq, Jul 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum. {ECO:0000255|HAMAP-Rule:MF_03058, ECO:0000269|PubMed:19379691}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|VMA21|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|vacuolar proton-transporting V-type ATPase complex assembly|
|proton-transporting V-type ATPase complex assembly|
|proton-transporting two-sector ATPase complex assembly|
|vacuole|
|ER to Golgi transport vesicle membrane|
|endoplasmic reticulum-Golgi intermediate compartment membrane|
|regulation of ATPase activity|
|lysosome|
|cellular protein-containing complex assembly|
|endoplasmic reticulum membrane|
|regulation of hydrolase activity|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|-2.44|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|-2.22|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-2.21|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|-2.21|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-2.04|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-1.96|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|-1.86|
|[[:results:exp336|Asunaprenir 3μM R07 exp336]]|-1.81|
|[[:results:exp260|ABT-702 0.1μM R06 exp260]]|-1.78|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-1.76|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|-1.75|
|[[:results:exp302|35°C R06 exp302]]|-1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:timm22|TIMM22]]|0.476|
|[[:human genes:c:ccdc115|CCDC115]]|0.465|
|[[:human genes:r:rabggtb|RABGGTB]]|0.448|
|[[:human genes:d:dpagt1|DPAGT1]]|0.448|
|[[:human genes:d:dolk|DOLK]]|0.445|
|[[:human genes:d:dhrsx|DHRSX]]|0.429|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.425|
|[[:human genes:h:htt|HTT]]|0.418|
|[[:human genes:a:alg1|ALG1]]|0.412|
|[[:human genes:w:wdr92|WDR92]]|0.411|
|[[:human genes:s:srd5a3|SRD5A3]]|0.403|
|[[:human genes:c:cdipt|CDIPT]]|0.402|
|[[:human genes:d:ddx20|DDX20]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 20/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|1/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|1/18|
|liver|1/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|2/12|
|prostate|0/1|
|skin|1/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|2/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1575
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='VMA21 Expression in NALM6 Cells: 5.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>