VNN1 [The Human Chemical-Genetic Interaction Map Project]

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======= VNN1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: VNN1
  * **<color #00a2e8>Official Name</color>**: vanin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8876|8876]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95497|O95497]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=VNN1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20VNN1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603570|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the vanin family of proteins, which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. This protein, like its mouse homolog, is likely a GPI-anchored cell surface molecule. The mouse protein is expressed by the perivascular thymic stromal cells and regulates migration of T-cell progenitors to the thymus. This gene lies in close proximity to, and in the same transcriptional orientation as, two other vanin genes on chromosome 6q23-q24. [provided by RefSeq, Feb 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine. {ECO:0000269|PubMed:10567687, ECO:0000269|PubMed:11491533, ECO:0000269|PubMed:25478849}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CN hydrolase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|pantetheine hydrolase activity|
|pantothenate metabolic process|
|positive regulation of T cell differentiation in thymus|
|chronic inflammatory response|
|negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|
|regulation of T cell differentiation in thymus|
|regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|
|negative regulation of oxidative stress-induced cell death|
|negative regulation of cellular response to oxidative stress|
|negative regulation of response to oxidative stress|
|azurophil granule membrane|
|regulation of oxidative stress-induced cell death|
|acute inflammatory response|
|regulation of cellular response to oxidative stress|
|positive regulation of T cell differentiation|
|regulation of response to oxidative stress|
|water-soluble vitamin metabolic process|
|positive regulation of lymphocyte differentiation|
|negative regulation of intrinsic apoptotic signaling pathway|
|anchored component of membrane|
|vitamin metabolic process|
|regulation of T cell differentiation|
|positive regulation of leukocyte differentiation|
|regulation of intrinsic apoptotic signaling pathway|
|regulation of lymphocyte differentiation|
|positive regulation of hemopoiesis|
|cellular modified amino acid metabolic process|
|positive regulation of T cell activation|
|positive regulation of leukocyte cell-cell adhesion|
|negative regulation of apoptotic signaling pathway|
|coenzyme metabolic process|
|positive regulation of cell-cell adhesion|
|regulation of leukocyte differentiation|
|regulation of leukocyte cell-cell adhesion|
|regulation of T cell activation|
|positive regulation of lymphocyte activation|
|response to oxidative stress|
|regulation of cell-cell adhesion|
|regulation of apoptotic signaling pathway|
|positive regulation of cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|cofactor metabolic process|
|regulation of hemopoiesis|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|inflammatory response|
|neutrophil mediated immunity|
|neutrophil activation|
|cell-cell adhesion|
|granulocyte activation|
|negative regulation of intracellular signal transduction|
|leukocyte degranulation|
|regulation of lymphocyte activation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|monocarboxylic acid metabolic process|
|myeloid leukocyte activation|
|regulation of leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulation of cell activation|
|regulation of cell adhesion|
|regulated exocytosis|
|regulation of cellular response to stress|
|leukocyte mediated immunity|
|innate immune response|
|cellular amide metabolic process|
|exocytosis|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|carboxylic acid metabolic process|
|leukocyte activation|
|cell adhesion|
|biological adhesion|
|defense response to other organism|
|positive regulation of cell differentiation|
|negative regulation of cell death|
|oxoacid metabolic process|
|secretion by cell|
|organic acid metabolic process|
|export from cell|
|cell activation|
|immune effector process|
|secretion|
|positive regulation of immune system process|
|negative regulation of signal transduction|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|regulation of response to stress|
|regulation of apoptotic process|
|regulation of programmed cell death|
|negative regulation of response to stimulus|
|regulation of immune system process|
|regulation of cell death|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|regulation of cell differentiation|
|regulation of intracellular signal transduction|
|immune response|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17335
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='VNN1 Expression in NALM6 Cells: 0.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>