VPS51 [The Human Chemical-Genetic Interaction Map Project]

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======= VPS51 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: VPS51
  * **<color #00a2e8>Official Name</color>**: VPS51 subunit of GARP complex
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=738|738]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UID3|Q9UID3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=VPS51&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20VPS51|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615738|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. VPS51 participates in retrograde transport of acid hydrolase receptors, likely by promoting tethering and SNARE-dependent fusion of endosome-derived carriers to the TGN (PubMed:20685960). Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane (PubMed:25799061). {ECO:0000269|PubMed:20685960, ECO:0000269|PubMed:25799061}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Dor1|
|Vps51|
|DUF2450|
|COG2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|EARP complex|
|GARP complex|
|endocytic recycling|
|retrograde transport, endosome to Golgi|
|trans-Golgi network membrane|
|lysosomal transport|
|recycling endosome|
|Golgi organization|
|vacuolar transport|
|cytosolic transport|
|trans-Golgi network|
|endosomal transport|
|process utilizing autophagic mechanism|
|autophagy|
|lipid transport|
|lipid localization|
|Golgi vesicle transport|
|endomembrane system organization|
|intracellular membrane-bounded organelle|
|molecular function|
|nucleolus|
|Golgi apparatus|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|establishment of protein localization|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-2.96|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-2.83|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-2.59|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-2.54|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|-2.35|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-2.27|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-2.26|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-2.21|
|[[:results:exp496|Lead acetate 990μM R08 exp496]]|-2.16|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-2.07|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-2|
|[[:results:exp453|B02 10μM R08 exp453]]|-1.99|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|-1.94|
|[[:results:exp433|LJH685 50μM R08 exp433]]|-1.92|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-1.89|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-1.89|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|-1.81|
|[[:results:exp20|Etoposide 10μM R00 exp20]]|-1.8|
|[[:results:exp17|DABN 20μM R00 exp17]]|-1.78|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|-1.76|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|-1.72|
|[[:results:exp473|Cincreasin 100μM R08 exp473]]|-1.7|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|-1.7|
|[[:results:exp142|OICR-9429 10μM R03 exp142]]|1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:v:vps52|VPS52]]|0.469|
|[[:human genes:p:polr1a|POLR1A]]|0.435|
|[[:human genes:p:psmb4|PSMB4]]|0.423|
|[[:human genes:p:pola1|POLA1]]|0.421|
|[[:human genes:c:copa|COPA]]|0.418|
|[[:human genes:v:vps28|VPS28]]|0.417|
|[[:human genes:p:polr2j3|POLR2J3]]|0.41|
|[[:human genes:p:psmb2|PSMB2]]|0.41|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 289/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|15/28|
|blood|12/28|
|bone|7/26|
|breast|11/33|
|central nervous system|19/56|
|cervix|2/4|
|colorectal|4/17|
|esophagus|6/13|
|fibroblast|1/1|
|gastric|8/16|
|kidney|9/21|
|liver|8/20|
|lung|26/75|
|lymphocyte|10/16|
|ovary|5/26|
|pancreas|9/24|
|peripheral nervous system|6/16|
|plasma cell|12/15|
|prostate|1/1|
|skin|8/24|
|soft tissue|3/9|
|thyroid|0/2|
|upper aerodigestive|13/22|
|urinary tract|15/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 275
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.45 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='VPS51 Expression in NALM6 Cells: 5.45'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>