VWA2 [The Human Chemical-Genetic Interaction Map Project]

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======= VWA2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: VWA2
  * **<color #00a2e8>Official Name</color>**: von Willebrand factor A domain containing 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=340706|340706]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5GFL6|Q5GFL6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=VWA2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20VWA2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618281|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|EGF|
|VWA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|calcium-independent cell-matrix adhesion|
|growth plate cartilage chondrocyte morphogenesis|
|chondrocyte morphogenesis|
|chondrocyte morphogenesis involved in endochondral bone morphogenesis|
|growth plate cartilage morphogenesis|
|growth plate cartilage chondrocyte differentiation|
|chondrocyte development involved in endochondral bone morphogenesis|
|cartilage morphogenesis|
|chondrocyte differentiation involved in endochondral bone morphogenesis|
|growth plate cartilage development|
|endochondral bone growth|
|chondrocyte development|
|cartilage development involved in endochondral bone morphogenesis|
|bone growth|
|regulation of insulin receptor signaling pathway|
|regulation of cellular response to insulin stimulus|
|endochondral bone morphogenesis|
|chondrocyte differentiation|
|basement membrane|
|organ growth|
|bone morphogenesis|
|cell-matrix adhesion|
|cartilage development|
|cell-substrate adhesion|
|bone development|
|connective tissue development|
|extracellular matrix|
|skeletal system morphogenesis|
|protein homooligomerization|
|collagen-containing extracellular matrix|
|developmental growth|
|growth|
|skeletal system development|
|protein complex oligomerization|
|cell morphogenesis involved in differentiation|
|tissue morphogenesis|
|calcium ion binding|
|cell morphogenesis|
|cellular component morphogenesis|
|cell adhesion|
|biological adhesion|
|animal organ morphogenesis|
|identical protein binding|
|protein-containing complex assembly|
|extracellular space|
|cell development|
|tissue development|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|-1.96|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|1.71|
|[[:results:exp406|Thalidomide 20μM R07 exp406]]|1.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.405|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8236
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.95 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='VWA2 Expression in NALM6 Cells: -1.95'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>