WAPAL [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= WAPAL =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: WAPL
  * **<color #00a2e8>Official Name</color>**: WAPL cohesin release factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23063|23063]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7Z5K2|Q7Z5K2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=WAPAL&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20WAPAL|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610754|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Involved in both sister chromatid cohesion during interphase and sister- chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. {ECO:0000269|PubMed:15150110, ECO:0000269|PubMed:17112726, ECO:0000269|PubMed:17113138, ECO:0000269|PubMed:19696148, ECO:0000269|PubMed:19907496, ECO:0000269|PubMed:21111234, ECO:0000269|PubMed:23776203}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WAPL|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of chromosome condensation|
|negative regulation of sister chromatid cohesion|
|regulation of cohesin loading|
|regulation of protein localization to chromatin|
|negative regulation of chromatin binding|
|cohesin complex|
|regulation of sister chromatid cohesion|
|regulation of chromatin binding|
|protein localization to chromatin|
|synaptonemal complex|
|negative regulation of sister chromatid segregation|
|negative regulation of chromosome segregation|
|negative regulation of DNA replication|
|positive regulation of fibroblast proliferation|
|chromosome, centromeric region|
|protein localization to chromosome|
|regulation of sister chromatid segregation|
|regulation of fibroblast proliferation|
|meiotic chromosome segregation|
|regulation of chromosome segregation|
|regulation of DNA replication|
|chromatin|
|chromosome|
|regulation of DNA binding|
|negative regulation of chromosome organization|
|meiotic nuclear division|
|meiotic cell cycle process|
|negative regulation of binding|
|nuclear chromosome segregation|
|meiotic cell cycle|
|chromosome segregation|
|nuclear division|
|organelle fission|
|negative regulation of cell cycle process|
|regulation of chromosome organization|
|negative regulation of organelle organization|
|regulation of binding|
|cell division|
|response to toxic substance|
|regulation of cellular protein localization|
|negative regulation of cell cycle|
|mitotic cell cycle|
|viral process|
|negative regulation of cellular component organization|
|protein localization to organelle|
|regulation of cell cycle process|
|symbiotic process|
|interspecies interaction between organisms|
|positive regulation of cell population proliferation|
|regulation of cellular localization|
|cell cycle process|
|regulation of protein localization|
|negative regulation of molecular function|
|regulation of cell cycle|
|regulation of organelle organization|
|cell cycle|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|cellular protein localization|
|cellular macromolecule localization|
|regulation of cell population proliferation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-3.2|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-2.69|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|-2.58|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-2.58|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-2.5|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-2.43|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|-2.26|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-2.26|
|[[:results:exp17|DABN 20μM R00 exp17]]|-1.87|
|[[:results:exp280|Daidzin 10μM R06 exp280]]|-1.86|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-1.73|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|-1.73|
|[[:results:exp318|ABT-702 5μM R07 exp318]]|1.74|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|1.74|
|[[:results:exp129|Isonicotinamide 500μM R03 exp129]]|1.8|
|[[:results:exp131|L-74142 5μM R03 exp131]]|1.85|
|[[:results:exp100|NFN1 1μM R03 exp100]]|1.87|
|[[:results:exp345|Cidofovir 10μM R07 exp345]]|2.16|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.504|
|[[:human genes:i:ik|IK]]|0.471|
|[[:human genes:p:psmb3|PSMB3]]|0.443|
|[[:human genes:t:twistnb|TWISTNB]]|0.428|
|[[:human genes:r:rpl9|RPL9]]|0.427|
|[[:human genes:c:ccna2|CCNA2]]|0.426|
|[[:human genes:c:chd4|CHD4]]|0.423|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.413|
|[[:human genes:p:pi4kb|PI4KB]]|0.41|
|[[:human genes:m:myb|MYB]]|0.408|
|[[:human genes:s:slc6a17|SLC6A17]]|0.407|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.406|
|[[:human genes:p:polr2j|POLR2J]]|0.404|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1144
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='WAPAL Expression in NALM6 Cells: 7.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>