WASF2 [The Human Chemical-Genetic Interaction Map Project]

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======= WASF2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: WASF2
  * **<color #00a2e8>Official Name</color>**: WASP family member 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10163|10163]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y6W5|Q9Y6W5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=WASF2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20WASF2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605875|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. {ECO:0000269|PubMed:10381382, ECO:0000269|PubMed:16275905}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|lamellipodium morphogenesis|
|SCAR complex|
|postsynaptic actin cytoskeleton organization|
|postsynaptic cytoskeleton organization|
|megakaryocyte development|
|positive regulation of lamellipodium assembly|
|negative regulation of stress fiber assembly|
|Rac protein signal transduction|
|megakaryocyte differentiation|
|negative regulation of actin filament bundle assembly|
|bone cell development|
|protein kinase A binding|
|positive regulation of lamellipodium organization|
|regulation of lamellipodium assembly|
|lamellipodium assembly|
|lamellipodium organization|
|regulation of lamellipodium organization|
|myeloid cell development|
|vascular endothelial growth factor receptor signaling pathway|
|regulation of stress fiber assembly|
|postsynapse organization|
|regulation of actomyosin structure organization|
|ruffle|
|regulation of actin filament bundle assembly|
|positive regulation of plasma membrane bounded cell projection assembly|
|actin filament-based movement|
|negative regulation of supramolecular fiber organization|
|SH3 domain binding|
|immune response-regulating cell surface receptor signaling pathway involved in phagocytosis|
|Fc-gamma receptor signaling pathway involved in phagocytosis|
|Fc receptor mediated stimulatory signaling pathway|
|negative regulation of cytoskeleton organization|
|Fc-gamma receptor signaling pathway|
|ameboidal-type cell migration|
|cell-cell junction|
|lamellipodium|
|bone development|
|regulation of plasma membrane bounded cell projection assembly|
|regulation of cell projection assembly|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|actin cytoskeleton|
|myeloid cell differentiation|
|Fc receptor signaling pathway|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|Ras protein signal transduction|
|early endosome|
|regulation of actin filament organization|
|actin binding|
|synapse|
|synapse organization|
|cadherin binding|
|angiogenesis|
|small GTPase mediated signal transduction|
|phagocytosis|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|negative regulation of organelle organization|
|positive regulation of cell projection organization|
|regulation of actin filament-based process|
|blood vessel morphogenesis|
|plasma membrane bounded cell projection assembly|
|immune response-activating cell surface receptor signaling pathway|
|cell projection assembly|
|immune response-regulating cell surface receptor signaling pathway|
|plasma membrane bounded cell projection morphogenesis|
|blood vessel development|
|cell projection morphogenesis|
|skeletal system development|
|actin cytoskeleton organization|
|vasculature development|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|cell part morphogenesis|
|cardiovascular system development|
|positive regulation of cellular component biogenesis|
|regulation of cytoskeleton organization|
|endocytosis|
|hemopoiesis|
|immune response-activating signal transduction|
|actin filament-based process|
|protein-containing complex|
|immune response-regulating signaling pathway|
|hematopoietic or lymphoid organ development|
|activation of immune response|
|immune system development|
|tube morphogenesis|
|import into cell|
|regulation of plasma membrane bounded cell projection organization|
|viral process|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|symbiotic process|
|interspecies interaction between organisms|
|cellular component morphogenesis|
|tube development|
|positive regulation of immune response|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|regulation of cellular component biogenesis|
|cell migration|
|localization of cell|
|cell motility|
|immune effector process|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|positive regulation of immune system process|
|regulation of immune response|
|cell projection organization|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|locomotion|
|G protein-coupled receptor signaling pathway|
|movement of cell or subcellular component|
|cell development|
|regulation of immune system process|
|intracellular signal transduction|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|-1.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18542
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.37 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='WASF2 Expression in NALM6 Cells: 7.37'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>