WASL [The Human Chemical-Genetic Interaction Map Project]

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======= WASL =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: WASL
  * **<color #00a2e8>Official Name</color>**: WASP like actin nucleation promoting factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8976|8976]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O00401|O00401]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=WASL&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20WASL|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605056|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Regulates actin polymerization by stimulating the actin- nucleating activity of the Arp2/3 complex. Involved in mitosis and cytokinesis, via its role in the regulation of actin polymerization. Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression. Plays a role in dendrite spine morphogenesis (By similarity). {ECO:0000250|UniProtKB:Q91YD9, ECO:0000269|PubMed:19366662, ECO:0000269|PubMed:19487689, ECO:0000269|PubMed:22847007, ECO:0000269|PubMed:22921828}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WH2|
|PBD|
|WH1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of membrane tubulation|
|actin cap|
|positive regulation of clathrin-dependent endocytosis|
|vesicle transport along actin filament|
|actin cortical patch organization|
|actin cortical patch assembly|
|regulation of membrane tubulation|
|actin cortical patch localization|
|actin filament-based transport|
|positive regulation of Arp2/3 complex-mediated actin nucleation|
|GTPase regulator activity|
|negative regulation of lymphocyte migration|
|regulation of plasma membrane organization|
|positive regulation of actin nucleation|
|regulation of Arp2/3 complex-mediated actin nucleation|
|actin cortical patch|
|regulation of clathrin-dependent endocytosis|
|dendritic spine morphogenesis|
|cellular protein-containing complex localization|
|regulation of actin nucleation|
|dendritic spine development|
|positive regulation of filopodium assembly|
|dendritic spine organization|
|actin filament polymerization|
|neuron projection organization|
|cortical actin cytoskeleton organization|
|regulation of nitric-oxide synthase activity|
|regulation of filopodium assembly|
|negative regulation of leukocyte migration|
|cortical cytoskeleton organization|
|spindle localization|
|vesicle cytoskeletal trafficking|
|actin polymerization or depolymerization|
|positive regulation of receptor-mediated endocytosis|
|regulation of monooxygenase activity|
|dendrite morphogenesis|
|regulation of lymphocyte migration|
|endocytic vesicle membrane|
|actin filament|
|ephrin receptor signaling pathway|
|protein polymerization|
|postsynapse organization|
|positive regulation of actin filament polymerization|
|regulation of oxidoreductase activity|
|vesicle budding from membrane|
|regulation of receptor-mediated endocytosis|
|positive regulation of endocytosis|
|positive regulation of plasma membrane bounded cell projection assembly|
|dendrite development|
|actin filament-based movement|
|positive regulation of protein polymerization|
|Fc-gamma receptor signaling pathway involved in phagocytosis|
|immune response-regulating cell surface receptor signaling pathway involved in phagocytosis|
|Fc receptor mediated stimulatory signaling pathway|
|Fc-gamma receptor signaling pathway|
|regulation of actin filament polymerization|
|establishment of vesicle localization|
|cytoskeleton-dependent intracellular transport|
|lamellipodium|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|vesicle localization|
|regulation of leukocyte migration|
|positive regulation of supramolecular fiber organization|
|regulation of plasma membrane bounded cell projection assembly|
|regulation of cell projection assembly|
|actin filament binding|
|regulation of endocytosis|
|actin cytoskeleton|
|positive regulation of cytoskeleton organization|
|regulation of protein polymerization|
|actin filament organization|
|Fc receptor signaling pathway|
|positive regulation of protein complex assembly|
|cytoplasmic vesicle|
|protein-containing complex localization|
|negative regulation of cell migration|
|regulation of actin filament organization|
|synapse organization|
|negative regulation of cell motility|
|vesicle organization|
|negative regulation of cellular component movement|
|negative regulation of locomotion|
|phagocytosis|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|establishment of organelle localization|
|regulation of cellular component size|
|positive regulation of cell projection organization|
|regulation of actin filament-based process|
|cell morphogenesis involved in neuron differentiation|
|negative regulation of immune system process|
|immune response-activating cell surface receptor signaling pathway|
|regulation of protein complex assembly|
|supramolecular fiber organization|
|neuron projection morphogenesis|
|immune response-regulating cell surface receptor signaling pathway|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|cell division|
|actin cytoskeleton organization|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|cell part morphogenesis|
|regulation of anatomical structure size|
|positive regulation of cellular component biogenesis|
|regulation of cytoskeleton organization|
|regulation of vesicle-mediated transport|
|endocytosis|
|cell morphogenesis involved in differentiation|
|immune response-activating signal transduction|
|actin filament-based process|
|organelle localization|
|immune response-regulating signaling pathway|
|positive regulation of organelle organization|
|activation of immune response|
|neuron projection development|
|import into cell|
|response to bacterium|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|neuron development|
|cellular component morphogenesis|
|cellular protein-containing complex assembly|
|regulation of cell migration|
|membrane organization|
|positive regulation of immune response|
|regulation of cell motility|
|regulation of cellular component biogenesis|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|cell cycle process|
|neuron differentiation|
|regulation of protein localization|
|immune effector process|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|regulation of immune response|
|positive regulation of immune system process|
|cell projection organization|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|cell cycle|
|intracellular transport|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|movement of cell or subcellular component|
|protein-containing complex assembly|
|cellular protein localization|
|cellular macromolecule localization|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|regulation of immune system process|
|positive regulation of RNA metabolic process|
|establishment of localization in cell|
|protein-containing complex subunit organization|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11886
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='WASL Expression in NALM6 Cells: 3.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>