WDHD1 [The Human Chemical-Genetic Interaction Map Project]

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======= WDHD1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: WDHD1
  * **<color #00a2e8>Official Name</color>**: WD repeat and HMG-box DNA binding protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11169|11169]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75717|O75717]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=WDHD1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20WDHD1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608126|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. {ECO:0000269|PubMed:19805216}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WD40|
|DUF3639|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|replication fork protection complex|
|nuclear replication fork|
|DNA-dependent DNA replication|
|DNA replication|
|chromatin binding|
|DNA repair|
|mitotic cell cycle|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|cell cycle|
|DNA binding|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp295|Pyronaridine 1μM R06 exp295]]|-1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.407|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 587/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|25/28|
|blood|21/28|
|bone|24/25|
|breast|27/33|
|central nervous system|50/56|
|cervix|2/4|
|colorectal|13/17|
|esophagus|6/13|
|fibroblast|1/1|
|gastric|14/15|
|kidney|17/21|
|liver|17/20|
|lung|64/75|
|lymphocyte|9/14|
|ovary|20/26|
|pancreas|20/24|
|peripheral nervous system|15/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|20/24|
|soft tissue|7/7|
|thyroid|2/2|
|upper aerodigestive|12/22|
|urinary tract|21/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1750
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='WDHD1 Expression in NALM6 Cells: 6.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>