WDPCP [The Human Chemical-Genetic Interaction Map Project]

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======= WDPCP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: WDPCP
  * **<color #00a2e8>Official Name</color>**: WD repeat containing planar cell polarity effector
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51057|51057]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95876|O95876]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=WDPCP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20WDPCP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613580|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a cytoplasmic WD40 repeat protein. A similar gene in frogs encodes a planar cell polarity protein that plays a critical role in collective cell movement and ciliogenesis by mediating septin localization. Mutations in this gene are associated with Bardet-Biedl syndrome 15 and may also play a role in Meckel-Gruber syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Probable effector of the planar cell polarity signaling pathway which regulates the septin cytoskeleton in both ciliogenesis and collective cell movements. Together with FUZ and WDPCP proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (By similarity). {ECO:0000250|UniProtKB:Q32NR9, ECO:0000250|UniProtKB:Q8C456}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF3312|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|axonemal basal plate|
|septin cytoskeleton organization|
|regulation of embryonic cell shape|
|glomerular visceral epithelial cell migration|
|auditory receptor cell morphogenesis|
|auditory receptor cell development|
|regulation of establishment of cell polarity|
|regulation of establishment or maintenance of cell polarity|
|inner ear auditory receptor cell differentiation|
|regulation of fibroblast migration|
|regulation of ruffle assembly|
|hair cell differentiation|
|inner ear receptor cell development|
|neuroepithelial cell differentiation|
|columnar/cuboidal epithelial cell development|
|inner ear receptor cell differentiation|
|mechanoreceptor differentiation|
|regulation of focal adhesion assembly|
|regulation of cell-substrate junction assembly|
|embryonic digit morphogenesis|
|regulation of adherens junction organization|
|smoothened signaling pathway|
|epithelial cell migration|
|epithelium migration|
|regulation of cell junction assembly|
|roof of mouth development|
|tissue migration|
|columnar/cuboidal epithelial cell differentiation|
|inner ear morphogenesis|
|axoneme|
|regulation of cell-matrix adhesion|
|ear morphogenesis|
|embryonic appendage morphogenesis|
|embryonic limb morphogenesis|
|regulation of embryonic development|
|cell cortex|
|digestive system development|
|appendage morphogenesis|
|limb morphogenesis|
|regulation of cell shape|
|ameboidal-type cell migration|
|limb development|
|appendage development|
|epithelial cell development|
|inner ear development|
|respiratory system development|
|regulation of plasma membrane bounded cell projection assembly|
|regulation of cell projection assembly|
|regulation of cell-substrate adhesion|
|ear development|
|sensory organ morphogenesis|
|kidney development|
|renal system development|
|embryonic organ morphogenesis|
|camera-type eye development|
|epidermal cell differentiation|
|apical plasma membrane|
|urogenital system development|
|cilium assembly|
|eye development|
|visual system development|
|sensory system development|
|cilium organization|
|epidermis development|
|cell morphogenesis involved in neuron differentiation|
|embryonic organ development|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|regulation of cell morphogenesis|
|cardiovascular system development|
|sensory organ development|
|cell morphogenesis involved in differentiation|
|embryonic morphogenesis|
|epithelial cell differentiation|
|regulation of cell adhesion|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|cell morphogenesis|
|organelle assembly|
|neuron development|
|cellular component morphogenesis|
|regulation of cell migration|
|circulatory system development|
|regulation of cell motility|
|animal organ morphogenesis|
|regulation of cellular component biogenesis|
|cell migration|
|embryo development|
|regulation of locomotion|
|regulation of cellular component movement|
|neuron differentiation|
|regulation of protein localization|
|regulation of anatomical structure morphogenesis|
|cell motility|
|localization of cell|
|cytoskeleton organization|
|epithelium development|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|locomotion|
|generation of neurons|
|movement of cell or subcellular component|
|establishment of protein localization|
|neurogenesis|
|cell development|
|tissue development|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|1.72|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|1.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13481
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.54 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='WDPCP Expression in NALM6 Cells: 5.54'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>