WDR11 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= WDR11 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: WDR11
  * **<color #00a2e8>Official Name</color>**: WD repeat domain 11
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55717|55717]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BZH6|Q9BZH6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=WDR11&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20WDR11|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606417|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is located in the chromosome 10q25-26 region, which is frequently deleted in gliomas and tumors of other tissues, and is disrupted by the t(10;19) translocation rearrangement in glioblastoma cells. The gene location suggests that it is a candidate gene for the tumor suppressor locus. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|vesicle tethering to Golgi|
|vesicle tethering|
|regulation of smoothened signaling pathway|
|multicellular organism growth|
|vesicle targeting|
|axoneme|
|ciliary basal body|
|microtubule cytoskeleton|
|trans-Golgi network|
|establishment of vesicle localization|
|vesicle localization|
|cytoplasmic vesicle|
|lysosomal membrane|
|cilium assembly|
|establishment of organelle localization|
|cilium organization|
|developmental growth|
|growth|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|heart development|
|organelle localization|
|organelle assembly|
|head development|
|circulatory system development|
|intracellular protein transport|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-3.24|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|-2.56|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|-2.27|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-2.19|
|[[:results:exp461|BS-181 20μM R08 exp461]]|-2.05|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|-2.02|
|[[:results:exp169|BH1 1μM R04 exp169]]|-1.98|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|-1.93|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|-1.89|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-1.79|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-1.75|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|-1.71|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|1.76|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|1.76|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|1.76|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|2.05|
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|2.24|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|4.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:f:fam91a1|FAM91A1]]|0.422|
|[[:human genes:c:col4a3bp|COL4A3BP]]|0.414|
|[[:human genes:t:tbc1d23|TBC1D23]]|0.411|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13981
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.23 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='WDR11 Expression in NALM6 Cells: 5.23'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>