WDR19 [The Human Chemical-Genetic Interaction Map Project]

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======= WDR19 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: WDR19
  * **<color #00a2e8>Official Name</color>**: WD repeat domain 19
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57728|57728]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8NEZ3|Q8NEZ3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=WDR19&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20WDR19|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608151|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the WD (tryptophan-aspartic acid) repeat family, which is a large family of structurally-related proteins known to participate in a wide range of cellular processes. Each WD repeat typically contains about 40 amino acids that are usually bracketed by glycine-histidine and tryptophan-aspartic acid (WD) dipeptides. This protein contains six WD repeats, three transmembrane domains, and a clathrin heavy-chain repeat. Mutations in this gene have been described in individuals with a wide range of disorders affecting function of the cilium. These disorders are known as ciliopathies, and include Jeune syndrome, Sensenbrenner syndromes, Senior-Loken syndrome, combined or isolated nephronophthisis (NPHP), and retinitis pigmentosa (RP). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport (PubMed:20889716). Involved in cilia function and/or assembly (By similarity). Associates with the BBSome complex to mediate ciliary transport (By similarity). {ECO:0000250|UniProtKB:Q3UGF1, ECO:0000269|PubMed:20889716}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|myotome development|
|ciliary receptor clustering involved in smoothened signaling pathway|
|intraciliary transport particle A|
|smoothened signaling pathway involved in dorsal/ventral neural tube patterning|
|protein localization to ciliary membrane|
|intraciliary retrograde transport|
|dorsal/ventral neural tube patterning|
|non-motile cilium|
|neural tube patterning|
|embryonic camera-type eye development|
|photoreceptor connecting cilium|
|intraciliary transport involved in cilium assembly|
|ciliary tip|
|embryonic cranial skeleton morphogenesis|
|protein localization to cilium|
|receptor clustering|
|intraciliary transport|
|photoreceptor outer segment|
|cranial skeletal system development|
|microtubule-based protein transport|
|protein transport along microtubule|
|smoothened signaling pathway|
|dorsal/ventral pattern formation|
|somite development|
|localization within membrane|
|embryonic skeletal system morphogenesis|
|motile cilium|
|ear morphogenesis|
|embryonic appendage morphogenesis|
|embryonic limb morphogenesis|
|embryonic skeletal system development|
|digestive system development|
|appendage morphogenesis|
|limb morphogenesis|
|transport along microtubule|
|neural tube development|
|cytoskeleton-dependent intracellular transport|
|limb development|
|appendage development|
|microtubule-based transport|
|cilium|
|gonad development|
|development of primary sexual characteristics|
|ear development|
|protein localization to cell periphery|
|skeletal system morphogenesis|
|sensory organ morphogenesis|
|protein-containing complex localization|
|sex differentiation|
|microtubule-based movement|
|nuclear body|
|embryonic organ morphogenesis|
|camera-type eye development|
|regionalization|
|cilium assembly|
|eye development|
|visual system development|
|cytoskeleton|
|sensory system development|
|cilium organization|
|in utero embryonic development|
|reproductive structure development|
|reproductive system development|
|embryonic organ development|
|pattern specification process|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|protein localization to membrane|
|skeletal system development|
|sensory organ development|
|embryonic morphogenesis|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|developmental process involved in reproduction|
|microtubule-based process|
|cell morphogenesis|
|protein localization to organelle|
|organelle assembly|
|cellular component morphogenesis|
|tube development|
|animal organ morphogenesis|
|embryo development|
|intracellular protein transport|
|epithelium development|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|nervous system process|
|reproductive process|
|reproduction|
|protein transport|
|intracellular transport|
|peptide transport|
|movement of cell or subcellular component|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|tissue development|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8275
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='WDR19 Expression in NALM6 Cells: 6.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>