WDR59 [The Human Chemical-Genetic Interaction Map Project]

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======= WDR59 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: WDR59
  * **<color #00a2e8>Official Name</color>**: WD repeat domain 59
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79726|79726]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6PJI9|Q6PJI9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=WDR59&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20WDR59|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617418|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:25457612, PubMed:27487210). {ECO:0000269|PubMed:23723238, ECO:0000269|PubMed:25457612, ECO:0000269|PubMed:27487210}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WD40|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|GATOR2 complex|
|positive regulation of TOR signaling|
|cellular response to amino acid starvation|
|response to amino acid starvation|
|regulation of TOR signaling|
|cellular response to starvation|
|response to starvation|
|cellular response to nutrient levels|
|cellular response to extracellular stimulus|
|lysosomal membrane|
|cellular response to external stimulus|
|response to nutrient levels|
|response to extracellular stimulus|
|positive regulation of intracellular signal transduction|
|positive regulation of signal transduction|
|cellular response to stress|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp484|GSK-J5 1.5μM R08 exp484]]|-2.44|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|-2.14|
|[[:results:exp534|Trientine 500μM R08 exp534]]|-1.95|
|[[:results:exp494|Isoniazid 100μM R08 exp494]]|-1.91|
|[[:results:exp331|A-769662 20μM R07 exp331]]|-1.87|
|[[:results:exp392|PT-1 25μM R07 exp392]]|-1.8|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|-1.75|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|-1.73|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|1.81|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|1.82|
|[[:results:exp211|AICAR 240μM R05 exp211]]|1.83|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|1.84|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|1.89|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|1.89|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|2.5|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|2.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:w:wdr24|WDR24]]|0.698|
|[[:human genes:r:rptor|RPTOR]]|0.68|
|[[:human genes:m:mios|MIOS]]|0.591|
|[[:human genes:d:dohh|DOHH]]|0.574|
|[[:human genes:t:thg1l|THG1L]]|0.57|
|[[:human genes:l:lamtor4|LAMTOR4]]|0.554|
|[[:human genes:m:mtor|MTOR]]|0.546|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.543|
|[[:human genes:a:alg1|ALG1]]|0.542|
|[[:human genes:d:dpagt1|DPAGT1]]|0.529|
|[[:human genes:m:mlst8|MLST8]]|0.524|
|[[:human genes:p:pelo|PELO]]|0.516|
|[[:human genes:l:lamtor2|LAMTOR2]]|0.514|
|[[:human genes:c:ccdc101|CCDC101]]|0.498|
|[[:human genes:g:gfpt1|GFPT1]]|0.496|
|[[:human genes:g:gmppb|GMPPB]]|0.495|
|[[:human genes:t:tmem41b|TMEM41B]]|0.489|
|[[:human genes:e:eif4e|EIF4E]]|0.488|
|[[:human genes:m:meaf6|MEAF6]]|0.487|
|[[:human genes:r:rtcb|RTCB]]|0.485|
|[[:human genes:p:plaa|PLAA]]|0.485|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.482|
|[[:human genes:m:med16|MED16]]|0.481|
|[[:human genes:n:nae1|NAE1]]|0.48|
|[[:human genes:a:atxn10|ATXN10]]|0.475|
|[[:human genes:t:tti2|TTI2]]|0.474|
|[[:human genes:r:rnmt|RNMT]]|0.474|
|[[:human genes:m:mllt1|MLLT1]]|0.473|
|[[:human genes:t:trnt1|TRNT1]]|0.471|
|[[:human genes:t:triap1|TRIAP1]]|0.47|
|[[:human genes:u:uhrf1|UHRF1]]|0.47|
|[[:human genes:u:uba3|UBA3]]|0.467|
|[[:human genes:e:eny2|ENY2]]|0.466|
|[[:human genes:u:uap1|UAP1]]|0.463|
|[[:human genes:c:casp9|CASP9]]|0.463|
|[[:human genes:p:pmm2|PMM2]]|0.462|
|[[:human genes:h:haus8|HAUS8]]|0.46|
|[[:human genes:u:urm1|URM1]]|0.459|
|[[:human genes:f:fbxo11|FBXO11]]|0.457|
|[[:human genes:d:dhps|DHPS]]|0.456|
|[[:human genes:g:gtf2a2|GTF2A2]]|0.455|
|[[:human genes:t:tbc1d5|TBC1D5]]|0.452|
|[[:human genes:l:lsm11|LSM11]]|0.449|
|[[:human genes:l:lamtor3|LAMTOR3]]|0.449|
|[[:human genes:a:alg2|ALG2]]|0.449|
|[[:human genes:t:thoc6|THOC6]]|0.449|
|[[:human genes:g:gnb1l|GNB1L]]|0.448|
|[[:human genes:z:zzz3|ZZZ3]]|0.445|
|[[:human genes:b:bak1|BAK1]]|0.445|
|[[:human genes:t:trmt10a|TRMT10A]]|0.444|
|[[:human genes:t:tbp|TBP]]|0.444|
|[[:human genes:d:dr1|DR1]]|0.444|
|[[:human genes:o:oraov1|ORAOV1]]|0.443|
|[[:human genes:e:eif4g1|EIF4G1]]|0.44|
|[[:human genes:a:apaf1|APAF1]]|0.439|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.439|
|[[:human genes:v:vezt|VEZT]]|0.437|
|[[:human genes:a:atp5j|ATP5J]]|0.437|
|[[:human genes:m:med23|MED23]]|0.435|
|[[:human genes:f:faf2|FAF2]]|0.435|
|[[:human genes:h:hspd1|HSPD1]]|0.432|
|[[:human genes:a:alg13|ALG13]]|0.432|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.43|
|[[:human genes:v:vhl|VHL]]|0.427|
|[[:human genes:a:atp5b|ATP5B]]|0.427|
|[[:human genes:t:tti1|TTI1]]|0.426|
|[[:human genes:c:cbfb|CBFB]]|0.426|
|[[:human genes:s:ssb|SSB]]|0.426|
|[[:human genes:z:znf592|ZNF592]]|0.424|
|[[:human genes:s:serf2|SERF2]]|0.422|
|[[:human genes:r:rraga|RRAGA]]|0.421|
|[[:human genes:h:hccs|HCCS]]|0.419|
|[[:human genes:p:polr3h|POLR3H]]|0.418|
|[[:human genes:r:rpp21|RPP21]]|0.418|
|[[:human genes:a:atic|ATIC]]|0.417|
|[[:human genes:b:bap1|BAP1]]|0.417|
|[[:human genes:i:id3|ID3]]|0.416|
|[[:human genes:f:flcn|FLCN]]|0.415|
|[[:human genes:a:adsl|ADSL]]|0.415|
|[[:human genes:t:telo2|TELO2]]|0.414|
|[[:human genes:f:fnip1|FNIP1]]|0.413|
|[[:human genes:e:exoc4|EXOC4]]|0.413|
|[[:human genes:t:trim28|TRIM28]]|0.413|
|[[:human genes:i:irf2|IRF2]]|0.411|
|[[:human genes:t:tgs1|TGS1]]|0.41|
|[[:human genes:s:seh1l|SEH1L]]|0.409|
|[[:human genes:n:nsd1|NSD1]]|0.409|
|[[:human genes:l:lamtor1|LAMTOR1]]|0.408|
|[[:human genes:b:bptf|BPTF]]|0.408|
|[[:human genes:l:lsm10|LSM10]]|0.407|
|[[:human genes:m:march5|MARCH5]]|0.407|
|[[:human genes:v:vps41|VPS41]]|0.407|
|[[:human genes:b:btaf1|BTAF1]]|0.406|
|[[:human genes:v:vdac2|VDAC2]]|0.406|
|[[:human genes:t:tbcb|TBCB]]|0.405|
|[[:human genes:c:csnk2b|CSNK2B]]|0.402|
|[[:human genes:t:trmt5|TRMT5]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3492
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='WDR59 Expression in NALM6 Cells: 6.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>