WDR62 [The Human Chemical-Genetic Interaction Map Project]

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======= WDR62 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: WDR62
  * **<color #00a2e8>Official Name</color>**: WD repeat domain 62
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=284403|284403]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43379|O43379]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=WDR62&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20WDR62|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613583|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is proposed to play a role in cerebral cortical development. Mutations in this gene have been associated with microencephaly, cortical malformations, and cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Required for cerebral cortical development. Plays a role in neuronal proliferation and migration (PubMed:20890278, PubMed:20729831). Plays a role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and CEP63 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). {ECO:0000269|PubMed:20729831, ECO:0000269|PubMed:20890278, ECO:0000269|PubMed:26297806}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WD40|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|centriole replication|
|centriole assembly|
|centrosome duplication|
|mitotic spindle organization|
|centrosome cycle|
|microtubule organizing center organization|
|microtubule cytoskeleton organization involved in mitosis|
|cerebral cortex development|
|spindle pole|
|centriole|
|spindle organization|
|microtubule organizing center|
|pallium development|
|telencephalon development|
|forebrain development|
|microtubule cytoskeleton organization|
|centrosome|
|mitotic cell cycle process|
|microtubule-based process|
|mitotic cell cycle|
|brain development|
|organelle assembly|
|head development|
|central nervous system development|
|cell cycle process|
|cytoskeleton organization|
|cell cycle|
|neurogenesis|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|-3.68|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|-3.66|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|-2.33|
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|-2.21|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|-1.86|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|-1.79|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|1.84|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|2|
|[[:results:exp59|UMK57 1μM R01 exp59]]|2.02|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|2.03|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|2.24|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:k:katna1|KATNA1]]|0.513|
|[[:human genes:k:katnb1|KATNB1]]|0.453|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4664
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.71 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='WDR62 Expression in NALM6 Cells: 6.71'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>