WDR7 [The Human Chemical-Genetic Interaction Map Project]

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======= WDR7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: WDR7
  * **<color #00a2e8>Official Name</color>**: WD repeat domain 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23335|23335]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y4E6|Q9Y4E6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=WDR7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20WDR7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613473|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WD40|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|hematopoietic progenitor cell differentiation|
|synaptic vesicle|
|hemopoiesis|
|hematopoietic or lymphoid organ development|
|immune system development|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-2.47|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-2.43|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-2.4|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|-2.18|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-2.12|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-2.05|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|-1.99|
|[[:results:exp336|Asunaprenir 3μM R07 exp336]]|-1.95|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-1.9|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-1.89|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|-1.86|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|-1.8|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-1.79|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|-1.78|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-1.76|
|[[:results:exp481|Ethambutol 25μM R08 exp481]]|-1.74|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-1.71|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-1.7|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|2.21|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:atp6v0a2|ATP6V0A2]]|0.639|
|[[:human genes:z:zfat|ZFAT]]|0.548|
|[[:human genes:a:atp6v1g1|ATP6V1G1]]|0.49|
|[[:human genes:c:cog7|COG7]]|0.456|
|[[:human genes:a:arl1|ARL1]]|0.455|
|[[:human genes:g:gpr107|GPR107]]|0.455|
|[[:human genes:c:cog5|COG5]]|0.427|
|[[:human genes:r:rgp1|RGP1]]|0.426|
|[[:human genes:s:sptlc2|SPTLC2]]|0.421|
|[[:human genes:p:pi4kb|PI4KB]]|0.417|
|[[:human genes:u:unc50|UNC50]]|0.413|
|[[:human genes:s:slc39a9|SLC39A9]]|0.409|
|[[:human genes:r:ruvbl2|RUVBL2]]|0.408|
|[[:human genes:p:prim1|PRIM1]]|0.408|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 549/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|23/28|
|blood|23/28|
|bone|20/26|
|breast|23/33|
|central nervous system|28/56|
|cervix|3/4|
|colorectal|12/17|
|esophagus|8/13|
|fibroblast|1/1|
|gastric|12/16|
|kidney|20/21|
|liver|17/20|
|lung|52/75|
|lymphocyte|14/16|
|ovary|17/26|
|pancreas|21/24|
|peripheral nervous system|10/16|
|plasma cell|12/15|
|prostate|0/1|
|skin|19/24|
|soft tissue|6/9|
|thyroid|1/2|
|upper aerodigestive|20/22|
|urinary tract|24/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1203
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.62 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='WDR7 Expression in NALM6 Cells: 5.62'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>