WDR81 [The Human Chemical-Genetic Interaction Map Project]

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======= WDR81 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: WDR81
  * **<color #00a2e8>Official Name</color>**: WD repeat domain 81
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=124997|124997]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q562E7|Q562E7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=WDR81&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20WDR81|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614218|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a multi-domain transmembrane protein which is predominantly expressed in the brain and is thought to play a role in endolysosomal trafficking. Mutations in this gene are associated with an autosomal recessive form of a syndrome exhibiting cerebellar ataxia, cognitive disability, and disequilibrium (CAMRQ2). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WD40|
|Beach|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phosphatidylinositol 3-kinase regulator activity|
|aggrephagy|
|extrinsic component of endosome membrane|
|selective autophagy|
|early endosome to late endosome transport|
|K63-linked polyubiquitin modification-dependent protein binding|
|vesicle-mediated transport between endosomal compartments|
|autophagosome membrane|
|regulation of phosphatidylinositol 3-kinase activity|
|regulation of lipid kinase activity|
|regulation of phospholipid metabolic process|
|negative regulation of phosphatase activity|
|negative regulation of dephosphorylation|
|late endosome membrane|
|cytosolic transport|
|early endosome membrane|
|macroautophagy|
|regulation of phosphatase activity|
|protein stabilization|
|regulation of dephosphorylation|
|autophagy|
|process utilizing autophagic mechanism|
|regulation of protein stability|
|lysosomal membrane|
|regulation of lipid metabolic process|
|mitochondrion organization|
|negative regulation of hydrolase activity|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|protein catabolic process|
|negative regulation of catalytic activity|
|regulation of kinase activity|
|cellular macromolecule catabolic process|
|endoplasmic reticulum membrane|
|regulation of transferase activity|
|Golgi apparatus|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|negative regulation of molecular function|
|mitochondrion|
|proteolysis|
|regulation of hydrolase activity|
|intracellular transport|
|regulation of phosphorylation|
|organic substance catabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|-2.94|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-2.86|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-2.74|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|-2.29|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|-1.86|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6944
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.95 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='WDR81 Expression in NALM6 Cells: 5.95'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>