WHSC1L1 [The Human Chemical-Genetic Interaction Map Project]

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======= WHSC1L1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NSD3
  * **<color #00a2e8>Official Name</color>**: nuclear receptor binding SET domain protein 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54904|54904]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BZ95|Q9BZ95]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=WHSC1L1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20WHSC1L1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607083|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is related to the Wolf-Hirschhorn syndrome candidate-1 gene and encodes a protein with PWWP (proline-tryptophan-tryptophan-proline) domains. This protein methylates histone H3 at lysine residues 4 and 27, which represses gene transcription. Two alternatively spliced variants have been described. [provided by RefSeq, May 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Histone methyltransferase. Preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression. {ECO:0000269|PubMed:16682010}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PWWP|
|SET|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of histone H3-K36 trimethylation|
|positive regulation of histone H3-K36 methylation|
|regulation of histone H3-K36 trimethylation|
|regulation of histone H3-K36 methylation|
|histone methyltransferase activity (H3-K36 specific)|
|histone H3-K36 methylation|
|histone-lysine N-methyltransferase activity|
|positive regulation of histone methylation|
|regulation of histone methylation|
|histone lysine methylation|
|peptidyl-lysine methylation|
|positive regulation of histone modification|
|histone methylation|
|positive regulation of chromatin organization|
|chromatin|
|protein alkylation|
|protein methylation|
|regulation of histone modification|
|positive regulation of chromosome organization|
|regulation of chromatin organization|
|macromolecule methylation|
|transcription coactivator activity|
|methylation|
|peptidyl-lysine modification|
|regulation of chromosome organization|
|histone modification|
|covalent chromatin modification|
|positive regulation of organelle organization|
|chromatin organization|
|peptidyl-amino acid modification|
|chromosome organization|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|regulation of organelle organization|
|positive regulation of transcription, DNA-templated|
|positive regulation of cellular protein metabolic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|-2.27|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|1.7|
|[[:results:exp145|PNU96415E 10μM R03 exp145]]|1.71|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|1.85|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|1.9|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|2.07|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10936
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.29 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='WHSC1L1 Expression in NALM6 Cells: 7.29'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>