WIPI2 [The Human Chemical-Genetic Interaction Map Project]

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======= WIPI2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: WIPI2
  * **<color #00a2e8>Official Name</color>**: WD repeat domain, phosphoinositide interacting 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=26100|26100]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y4P8|Q9Y4P8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=WIPI2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20WIPI2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609225|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Early component of the autophagy machinery being involved in formation of preautophagosomal structures and their maturation into mature phagosomes in response to phosphatidylinositol 3-phosphate (PtdIns3P). May bind PtdIns3P. {ECO:0000269|PubMed:20505359}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein lipidation involved in autophagosome assembly|
|xenophagy|
|C-terminal protein lipidation|
|protein localization to phagophore assembly site|
|C-terminal protein amino acid modification|
|phagophore assembly site membrane|
|selective autophagy|
|phagophore assembly site|
|phosphatidylinositol-3,5-bisphosphate binding|
|autophagosome maturation|
|mitochondrion disassembly|
|autophagy of mitochondrion|
|phosphatidylinositol-3-phosphate binding|
|autophagosome assembly|
|organelle disassembly|
|autophagosome organization|
|extrinsic component of membrane|
|autophagosome|
|protein lipidation|
|lipoprotein biosynthetic process|
|lipoprotein metabolic process|
|vacuole organization|
|cellular response to starvation|
|macroautophagy|
|response to starvation|
|cellular response to nutrient levels|
|protein-containing complex disassembly|
|process utilizing autophagic mechanism|
|autophagy|
|cellular response to extracellular stimulus|
|cellular response to external stimulus|
|post-translational protein modification|
|cellular component disassembly|
|mitochondrion organization|
|response to nutrient levels|
|response to extracellular stimulus|
|protein-containing complex|
|organelle assembly|
|defense response to other organism|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|organonitrogen compound biosynthetic process|
|cellular protein localization|
|cellular macromolecule localization|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|cellular catabolic process|
|protein-containing complex subunit organization|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp533|TNF-alpha 44ng/ml R08 exp533]]|-3.19|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-3.17|
|[[:results:exp359|FK-506 30μM R07 exp359]]|-2.25|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-2.17|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-2.11|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-1.93|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|-1.75|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|2.12|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|2.32|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|2.57|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|2.64|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|2.91|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|3.1|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|3.17|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|3.41|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:c12orf44|C12orf44]]|0.55|
|[[:human genes:a:atg9a|ATG9A]]|0.448|
|[[:human genes:r:rb1cc1|RB1CC1]]|0.444|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6676
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='WIPI2 Expression in NALM6 Cells: 6.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>