WNK1 [The Human Chemical-Genetic Interaction Map Project]

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======= WNK1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: WNK1
  * **<color #00a2e8>Official Name</color>**: WNK lysine deficient protein kinase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=65125|65125]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H4A3|Q9H4A3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=WNK1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20WNK1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605232|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the WNK subfamily of serine/threonine protein kinases. The encoded protein may be a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in this gene have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II. Alternatively spliced transcript variants encoding different isoforms have been described but the full-length nature of all of them has yet to be determined.[provided by RefSeq, May 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase|
|OSR1 C|
|Pkinase Tyr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of cell-cell adhesion mediated by integrin|
|lymphocyte migration into lymph node|
|signal transduction by trans-phosphorylation|
|lymphocyte migration into lymphoid organs|
|chemokine (C-C motif) ligand 21 signaling pathway|
|negative regulation of pancreatic juice secretion|
|regulation of pancreatic juice secretion|
|positive regulation of potassium ion import across plasma membrane|
|regulation of potassium ion import|
|potassium channel inhibitor activity|
|protein serine/threonine kinase inhibitor activity|
|regulation of cell-cell adhesion involved in gastrulation|
|chloride channel inhibitor activity|
|negative regulation of heterotypic cell-cell adhesion|
|negative regulation of cell adhesion mediated by integrin|
|regulation of cell-cell adhesion mediated by integrin|
|positive regulation of systemic arterial blood pressure|
|positive regulation of T cell chemotaxis|
|positive regulation of sodium ion transmembrane transporter activity|
|regulation of T cell chemotaxis|
|negative regulation of sodium ion transport|
|negative regulation of digestive system process|
|positive regulation of sodium ion transmembrane transport|
|positive regulation of lymphocyte chemotaxis|
|regulation of heterotypic cell-cell adhesion|
|regulation of lymphocyte chemotaxis|
|protein kinase activator activity|
|positive regulation of T cell migration|
|positive regulation of sodium ion transport|
|positive regulation of blood pressure|
|regulation of gastrulation|
|positive regulation of lymphocyte migration|
|positive regulation of potassium ion transmembrane transport|
|regulation of digestive system process|
|regulation of T cell migration|
|positive regulation of potassium ion transport|
|regulation of cell adhesion mediated by integrin|
|negative regulation of GTPase activity|
|phosphatase binding|
|regulation of sodium ion transmembrane transporter activity|
|regulation of lymphocyte migration|
|regulation of sodium ion transmembrane transport|
|lymphocyte migration|
|regulation of potassium ion transmembrane transport|
|chemokine-mediated signaling pathway|
|peptidyl-threonine phosphorylation|
|cellular response to calcium ion|
|regulation of sodium ion transport|
|positive regulation of leukocyte chemotaxis|
|response to chemokine|
|cellular response to chemokine|
|peptidyl-threonine modification|
|regulation of systemic arterial blood pressure|
|regulation of potassium ion transport|
|positive regulation of ion transmembrane transporter activity|
|negative regulation of phosphatase activity|
|negative regulation of dephosphorylation|
|positive regulation of transporter activity|
|regulation of leukocyte chemotaxis|
|negative regulation of leukocyte cell-cell adhesion|
|regulation of embryonic development|
|positive regulation of leukocyte migration|
|negative regulation of protein serine/threonine kinase activity|
|positive regulation of chemotaxis|
|positive regulation of cation transmembrane transport|
|positive regulation of canonical Wnt signaling pathway|
|negative regulation of ion transport|
|response to calcium ion|
|positive regulation of ion transmembrane transport|
|peptidyl-serine phosphorylation|
|negative regulation of cell-cell adhesion|
|T cell receptor signaling pathway|
|positive regulation of Wnt signaling pathway|
|regulation of phosphatase activity|
|regulation of blood pressure|
|cellular response to metal ion|
|protein autophosphorylation|
|regulation of leukocyte migration|
|peptidyl-serine modification|
|positive regulation of transmembrane transport|
|regulation of dephosphorylation|
|regulation of chemotaxis|
|magnesium ion binding|
|cellular response to inorganic substance|
|negative regulation of protein kinase activity|
|negative regulation of secretion|
|protein kinase activity|
|negative regulation of kinase activity|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|negative regulation of cell adhesion|
|positive regulation of ion transport|
|negative regulation of transferase activity|
|regulation of transporter activity|
|regulation of canonical Wnt signaling pathway|
|antigen receptor-mediated signaling pathway|
|regulation of leukocyte cell-cell adhesion|
|activation of protein kinase activity|
|regulation of cation transmembrane transport|
|regulation of Wnt signaling pathway|
|protein serine/threonine kinase activity|
|response to metal ion|
|leukocyte migration|
|regulation of metal ion transport|
|blood circulation|
|signal transduction by protein phosphorylation|
|circulatory system process|
|regulation of cell-cell adhesion|
|negative regulation of protein phosphorylation|
|negative regulation of phosphorylation|
|immune response-activating cell surface receptor signaling pathway|
|negative regulation of hydrolase activity|
|protein kinase binding|
|regulation of ion transmembrane transport|
|immune response-regulating cell surface receptor signaling pathway|
|regulation of GTPase activity|
|negative regulation of transport|
|regulation of body fluid levels|
|positive regulation of cell migration|
|regulation of protein serine/threonine kinase activity|
|positive regulation of cell motility|
|response to inorganic substance|
|positive regulation of protein kinase activity|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|immune response-activating signal transduction|
|regulation of transmembrane transport|
|positive regulation of kinase activity|
|regulation of system process|
|negative regulation of protein modification process|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|activation of immune response|
|positive regulation of transferase activity|
|cytokine-mediated signaling pathway|
|regulation of cell adhesion|
|regulation of ion transport|
|ion homeostasis|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|regulation of secretion|
|neuron development|
|regulation of cell migration|
|positive regulation of immune response|
|regulation of kinase activity|
|peptidyl-amino acid modification|
|regulation of cell motility|
|cell migration|
|protein phosphorylation|
|regulation of transferase activity|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|cellular response to cytokine stimulus|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|negative regulation of cellular protein metabolic process|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|localization of cell|
|cell motility|
|regulation of response to external stimulus|
|response to cytokine|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|negative regulation of molecular function|
|positive regulation of immune system process|
|regulation of immune response|
|negative regulation of multicellular organismal process|
|positive regulation of protein modification process|
|regulation of hydrolase activity|
|phosphorylation|
|locomotion|
|ion transport|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|ATP binding|
|generation of neurons|
|movement of cell or subcellular component|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|homeostatic process|
|cell development|
|regulation of immune system process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of protein modification process|
|regulation of transport|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-2.33|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|-2.3|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|-1.93|
|[[:results:exp101|Nicotinamide 1000μM R03 exp101]]|1.96|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|2.03|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|2.13|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.462|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 509/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|27/28|
|blood|23/28|
|bone|12/26|
|breast|20/33|
|central nervous system|25/56|
|cervix|1/4|
|colorectal|15/17|
|esophagus|12/13|
|fibroblast|0/1|
|gastric|14/16|
|kidney|19/21|
|liver|14/20|
|lung|48/75|
|lymphocyte|15/16|
|ovary|13/26|
|pancreas|21/24|
|peripheral nervous system|3/16|
|plasma cell|14/15|
|prostate|0/1|
|skin|21/24|
|soft tissue|4/9|
|thyroid|2/2|
|upper aerodigestive|16/22|
|urinary tract|23/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1046
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='WNK1 Expression in NALM6 Cells: 8.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>